1-Propanone, 2-methyl-1,3-diphenyl-, (2R)-

Base Information

• Chemical Name: 1-Propanone, 2-methyl-1,3-diphenyl-, (2R)-
• CAS No.: 159345-12-7
• Molecular Formula: C16H16O
• Molecular Weight: 224.302
• DSSTox Substance ID: DTXSID70451762
• Nikkaji Number: J60.619G
• Wikidata: Q82271967
• Mol file: 159345-12-7.mol

Synonyms:1-Propanone, 2-methyl-1,3-diphenyl-, (2R)-;159345-12-7;SCHEMBL8728691;DTXSID70451762;(alphaR)-alpha-Methyl-beta-phenylpropiophenone

Chemical Property of 1-Propanone, 2-methyl-1,3-diphenyl-, (2R)-

Chemical Property:

• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 224.120115130
• Heavy Atom Count: 17
• Complexity: 234

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC=CC=C1)C(=O)C2=CC=CC=C2
• Isomeric SMILES: C[C@H](CC1=CC=CC=C1)C(=O)C2=CC=CC=C2

Technology Process of 1-Propanone, 2-methyl-1,3-diphenyl-, (2R)-

There total 26 articles about 1-Propanone, 2-methyl-1,3-diphenyl-, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(2E)-2-methyl-1,3-diphenylprop-2-en-1-one (14182-01-5) → (2R)-1,3-diphenyl-2-methyl-propan-1-one (159345-12-7)

Guidance literature:

With C₂₄BF₂₀^(1-)*C₃₄H₃₆IrNPS⁽¹⁺⁾; hydrogen; In dichloromethane; at 20 ℃; for 16h; under 15001.5 Torr; enantioselective reaction;

DOI:10.1021/acs.orglett.0c04012

Reference yield: 98.0%

1,3-diphenyl-2-methylpropene-3-one (4258-37-1,14182-01-5,26709-60-4) → (2R)-1,3-diphenyl-2-methyl-propan-1-one (159345-12-7)

Guidance literature:

With C₃₂H₁₂BF₂₄^(1-)*C₄₆H₅₄IrNO₄PS⁽¹⁺⁾; hydrogen; In dichloromethane; at 20 ℃; for 18h; under 37503.8 Torr; enantioselective reaction; Autoclave;

DOI:10.1021/acs.joc.9b00829

Reference yield: 94.0%

phenyllithium (591-51-5) + (2R)-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-phenylpropionamide (159345-06-9,352530-53-1) → (2R)-1,3-diphenyl-2-methyl-propan-1-one (159345-12-7)

Guidance literature:

In tetrahydrofuran; at -78 - 0 ℃;

DOI:10.1021/ja00099a076

upstream raw materials:

phenyllithium

(2R)-N-[(1S,2S)-2-hydroxy-1-methyl-2-phenylethyl]-N,2-dimethyl-3-phenylpropionamide

phenylmagnesium bromide

(R)-2-Methyl-3-phenyl-thiopropionic acid S-benzyl ester