Ethyl benzoylcyanoacetate

Base Information

• Chemical Name: Ethyl benzoylcyanoacetate
• CAS No.: 1611-02-5
• Molecular Formula: C12H11NO3
• Molecular Weight: 217.224
• Mol file: 1611-02-5.mol

Synonyms:Methan-tricarbonsaeure-aethylester-anilid-nitril;2-cyano-N-phenyl-malonamic acid ethyl ester;Cyanmalonsaeure-aethylester-anilid;Benzenepropanoic acid, α-cyano-β-oxo-, ethyl ester;Cyanomalonsaeure-ethylester-anilid;Benzoylcyanessigsaeure-aethylester;2-Cyan-3-oxo-3-phenyl-propionsaeure-aethylester;2-cyano-3-oxo-3-phenyl-propionic acid ethyl ester;2-Cyan-N-phenyl-malonamidsaeure-aethylester;

Chemical Property of Ethyl benzoylcyanoacetate

Chemical Property:

• PSA: 67.16000
• LogP: 1.57218

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-cyano-3-oxo-3-phenylpropanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl benzoylcyanoacetate

There total 15 articles about Ethyl benzoylcyanoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

ethyl 2-cyanoacetate (105-56-6) + 3-acyl-2-oxazolone(R=Ph) (60759-50-4) → 2-cyano-3-oxo-3-phenyl-propionic acid ethyl ester (1611-02-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 ℃; for 0.333333h;

DOI:10.1016/S0040-4020(01)91572-8

Reference yield: 88.0%

benzoyl chloride (98-88-4) + ethyl 2-cyanoacetate (105-56-6) → 2-cyano-3-oxo-3-phenyl-propionic acid ethyl ester (1611-02-5)

Guidance literature:

ethyl 2-cyanoacetate; With ethanol; magnesium; In tetrachloromethane; toluene; for 1h; Heating;

benzoyl chloride; In tetrachloromethane; toluene; at 0 - 20 ℃; for 1.5h;

DOI:10.3987/COM-04-10216

Reference yield: 80.0%

ethyl 2-cyanoacetate (105-56-6) + benzoic acid (65-85-0,8013-63-6) → 2-cyano-3-oxo-3-phenyl-propionic acid ethyl ester (1611-02-5)

Guidance literature:

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 70 ℃; for 4h;

upstream raw materials:

quinoline

benzoyl chloride

ethyl 2-cyanoacetate

ethyl 3-oxo-3-phenylpropionate

Downstream raw materials:

2-cyano-3-methoxy-3-phenyl-acrylic acid ethyl ester

2-methyl-3-phenylpropylamine

Benzoylacetonitrile

ethyl 3-oxo-3-phenylpropionate