4-[4-(Bromomethyl)phenyl]-2,6-diphenylpyridine

Base Information

• Chemical Name: 4-[4-(Bromomethyl)phenyl]-2,6-diphenylpyridine
• CAS No.: 161121-63-7
• Molecular Formula: C24H18BrN
• Molecular Weight: 400.318
• DSSTox Substance ID: DTXSID40573708
• Wikidata: Q82462514
• Mol file: 161121-63-7.mol

Synonyms:4-[4-(Bromomethyl)phenyl]-2,6-diphenylpyridine;161121-63-7;DTXSID40573708;2,6-diphenyl-4-(p-bromomethylphenyl)pyridine

Chemical Property of 4-[4-(Bromomethyl)phenyl]-2,6-diphenylpyridine

Chemical Property:

• XLogP3: 6.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 399.06226
• Heavy Atom Count: 26
• Complexity: 378

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC(=CC(=N2)C3=CC=CC=C3)C4=CC=C(C=C4)CBr

Technology Process of 4-[4-(Bromomethyl)phenyl]-2,6-diphenylpyridine

There total 7 articles about 4-[4-(Bromomethyl)phenyl]-2,6-diphenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-(4-methylphenyl)-2,6-diphenylpyridine (3558-65-4) → 4-(4-(bromomethyl)phenyl)-2,6-diphenylpyridine (161121-63-7)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 1h; Heating;

DOI:10.1023/A:1020339120810

Reference yield:

acetophenone (98-86-2) → 4-(4-(bromomethyl)phenyl)-2,6-diphenylpyridine (161121-63-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 16 percent / 72 percent HClO₄ / toluene / 1 h / Heating

2: 78 percent / 25 percent aq. NH₄OH / 1.5 h / Heating

3: 95 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / 1 h / Heating

With ammonium hydroxide; N-Bromosuccinimide; perchloric acid; dibenzoyl peroxide; In tetrachloromethane; toluene;

DOI:10.1023/A:1020339120810

Reference yield:

4-methyl-benzaldehyde (104-87-0) → 4-(4-(bromomethyl)phenyl)-2,6-diphenylpyridine (161121-63-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium acetate; acetic acid / 24 h / 115 °C

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 24 h / 80 °C / Inert atmosphere

With N-Bromosuccinimide; ammonium acetate; acetic acid; dibenzoyl peroxide; In tetrachloromethane;

DOI:10.1039/c2jm30455d

upstream raw materials:

4-(4-methylphenyl)-2,6-diphenylpyridine

4-methyl-benzaldehyde

acetophenone

1,5-diphenyl-3-(p-methylphenyl)-1,5-pentanedione

Downstream raw materials:

2,6-diphenyl-4-(p-acetoxymethylphenyl)pyridine

4-(2,6-diphenylpyridin-4-yl)benzaldehyde

2,6-diphenyl-4-(p-hydroxymethylphenyl)pyridine

4-(4-(azidomethyl)phenyl)-2,6-diphenylpyridine