3-Iodo-5-methoxyphenol

Base Information

• Chemical Name: 3-Iodo-5-methoxyphenol
• CAS No.: 855839-41-7
• Molecular Formula: C7H7IO2
• Molecular Weight: 250.03375
• DSSTox Substance ID: DTXSID90698955
• Wikidata: Q82629563
• Mol file: 855839-41-7.mol

Synonyms:3-IODO-5-METHOXYPHENOL;855839-41-7;SCHEMBL13786716;DTXSID90698955;MB11865;FT-0707755

Chemical Property of 3-Iodo-5-methoxyphenol

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 249.94908
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

≥99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1)O)I

Technology Process of 3-Iodo-5-methoxyphenol

There total 3 articles about 3-Iodo-5-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3.5-dimethoxyaniline (10272-07-8) → 3-iodo-5-methoxyphenol (855839-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaSMe / N,N-dimethyl-acetamide / 140 °C

2.1: NaNO₂; HCl

2.2: KI

With hydrogenchloride; sodium nitrite; sodium thiomethoxide; In N,N-dimethyl acetamide;

DOI:10.1021/jo060727r

Reference yield:

3-amino-5-methoxyphenol (162155-27-3) → 3-iodo-5-methoxyphenol (855839-41-7)

Guidance literature:

3-amino-5-methoxyphenol; With hydrogenchloride; sodium nitrite;

With potassium iodide;

DOI:10.1021/jo060727r

Reference yield:

1-iodo-5-methoxy-phenylamine (62605-98-5) → 3-iodo-5-methoxyphenol (855839-41-7)

Guidance literature:

With sulfuric acid; Verkochen mit verd. Schwefelsaeure;

upstream raw materials:

1-iodo-5-methoxy-phenylamine

3-amino-5-methoxyphenol

3.5-dimethoxyaniline

Downstream raw materials:

5-iodoresorcinol