2-Amino-6-methoxypyridine-3,5-dicarbonitrile

Base Information

• Chemical Name: 2-Amino-6-methoxypyridine-3,5-dicarbonitrile
• CAS No.: 36926-81-5
• Molecular Formula: C8H6 N4 O
• Molecular Weight: 174.162
• NSC Number: 165418
• DSSTox Substance ID: DTXSID30304326
• Wikidata: Q82050171
• ChEMBL ID: CHEMBL1215033
• Mol file: 36926-81-5.mol

Synonyms:2-amino-6-methoxypyridine-3,5-dicarbonitrile;36926-81-5;CHEMBL1215033;NSC165418;DTXSID30304326;BDBM50324061;AKOS022638826;NSC-165418;NCGC00188750-01;F1957-0313

Chemical Property of 2-Amino-6-methoxypyridine-3,5-dicarbonitrile

Chemical Property:

• Vapor Pressure: 4.47E-06mmHg at 25°C
• Boiling Point: 383.2°C at 760 mmHg
• Flash Point: 185.6°C
• Density: 1.35g/cm³
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 174.05416083
• Heavy Atom Count: 13
• Complexity: 272

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C(=N1)N)C#N)C#N

Technology Process of 2-Amino-6-methoxypyridine-3,5-dicarbonitrile

There total 2 articles about 2-Amino-6-methoxypyridine-3,5-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

2-amino-6-chloropyridine-3,5-dicarbonitrile (51768-01-5) + sodium methylate (124-41-4) → 2-amino-6-methoxypyridine-3,5-dicarbonitrile (36926-81-5)

Guidance literature:

With methanol; for 1.5h; Reflux;

DOI:10.1016/j.bmc.2010.06.095

Reference yield:

→ 2-amino-6-methoxypyridine-3,5-dicarbonitrile (36926-81-5)

Guidance literature:

1, Malononitil;

Reference yield: 81.0%

1-phenylmethyl-4-piperidone (3612-20-2) + 2-amino-6-methoxypyridine-3,5-dicarbonitrile (36926-81-5) → 5-amino-7-benzyl-2-methoxy-6,7,8,9-tetrahydropyrido[2,3-b][1,6]naphthyridine-3-carbonitrile (1263199-64-9)

Guidance literature:

1-phenylmethyl-4-piperidone; 2-amino-6-methoxypyridine-3,5-dicarbonitrile; With trimethylsilyl trifluoromethanesulfonate; In ethyl acetate; for 20h; Heating; Microwave irradiation;

With water; sodium hydroxide; In ethanol;

DOI:10.1016/j.bmc.2010.11.040

upstream raw materials:

2-amino-6-chloropyridine-3,5-dicarbonitrile

sodium methylate

Downstream raw materials:

2-amino-6-(3-phenylpropoxy)pyridine-3,5-dicarbonitrile

5-amino-7-benzyl-2-methoxy-6,7,8,9-tetrahydropyrido[2,3-b][1,6]naphthyridine-3-carbonitrile