N-(2-Hydroxyethyl)-2-pyridinecarboxamide

Base Information

• Chemical Name: N-(2-Hydroxyethyl)-2-pyridinecarboxamide
• CAS No.: 16347-06-1
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Mol file: 16347-06-1.mol

Synonyms:N-(2-HYDROXYETHYL)-2-PYRIDINECARBOXAMIDE;N-(2-hydroxyethyl)pyridine-2-carboxamide;

Chemical Property of N-(2-Hydroxyethyl)-2-pyridinecarboxamide

Chemical Property:

• Melting Point: 113-114 °C
• Boiling Point: 190-191 °C(Press: 4 Torr)
• PKA: 12.88±0.46(Predicted)
• PSA: 62.22000
• Density: 1.212±0.06 g/cm3(Predicted)
• LogP: 0.19460
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

95% ^*data from raw suppliers

N-(2-Hydroxyethyl)pyridine-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-Hydroxyethyl)-2-pyridinecarboxamide

There total 10 articles about N-(2-Hydroxyethyl)-2-pyridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-[4,5-dihydro-1,3-oxazol-2-yl]pyridine (119165-69-4) → pyridine-2-(N-(2-hydroxyethyl)carboxamide) (16347-06-1)

Guidance literature:

With pyridinium perbromide hydrobromide; water; sodium methylate; at 20 ℃; for 17h; Reagent/catalyst;

DOI:10.3987/COM-17-13684

Reference yield: 92.0%

ethyl-2-picolinate (2524-52-9,1228273-66-2) + ethanolamine (141-43-5) → pyridine-2-(N-(2-hydroxyethyl)carboxamide) (16347-06-1)

Guidance literature:

at 20 - 55 ℃; for 18h;

DOI:10.1016/j.bmc.2014.03.011

Reference yield: 92.0%

2-bromo-pyridine (109-04-6) + carbon monoxide (201230-82-2) + ethanolamine (141-43-5) → pyridine-2-(N-(2-hydroxyethyl)carboxamide) (16347-06-1)

Guidance literature:

With C₅₁H₄₅NO₄P₂PdS; triethylamine; In 1,4-dioxane; at 45 ℃; for 16h; Sealed tube; Inert atmosphere;

DOI:10.1021/ol502014b

upstream raw materials:

ethyl-2-picolinate

ethanolamine

pyridine-2-carbonyl chloride

2-bromo-pyridine

Downstream raw materials:

N-(2-picolinoyl)-1,2-diaminoethane

2-[4,5-dihydro-1,3-oxazol-2-yl]pyridine