Indole-3-carboxaldehyde phenylhydrazone

Base Information

• Chemical Name: Indole-3-carboxaldehyde phenylhydrazone
• CAS No.: 16578-92-0
• Molecular Formula: C15H13N3
• Molecular Weight: 235.288
• Mol file: 16578-92-0.mol

Synonyms:Indol-3-aldehyd-phenylhydrazon;Indol-3-carbaldehyd-phenylhydrazon;indole-3-carbaldehyde phenylhydrazone;1-(Indolyl-3-methylen)-2-phenylhydrazin;3-indolecarbaldehyde phenylhydrazone;

Chemical Property of Indole-3-carboxaldehyde phenylhydrazone

Chemical Property:

• Melting Point: 198 °C
• Boiling Point: 450.2±27.0 °C(Predicted)
• PKA: 14.51±0.10(Predicted)
• PSA: 40.18000
• Density: 1.16±0.1 g/cm3(Predicted)
• LogP: 3.68690

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Indole-3-carboxaldehyde phenylhydrazone

There total 4 articles about Indole-3-carboxaldehyde phenylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) + phenylhydrazine (100-63-0) → 3-[(E)-(2-phenylhydrazinylidene) methyl]-1H-indole (16578-92-0)

Guidance literature:

With acetic acid; In ethanol; Reflux;

DOI:10.1007/s10895-021-02847-5

Reference yield: 92.0%

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) + phenylhydrazine (100-63-0) → 1-((1H-indol-3-yl)methylene)-2-phenylhydrazine (16578-92-0)

Guidance literature:

With oxaline; In neat (no solvent); at 25 - 30 ℃; for 0.05h; Green chemistry;

DOI:10.1016/j.molliq.2013.11.036

Reference yield:

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) + 4-fluorophenylhydrazine (371-14-2) → 3-[(E)-(2-phenylhydrazinylidene) methyl]-1H-indole (16578-92-0)

Guidance literature:

With hydrogenchloride; In ethanol; water; Reflux;

DOI:10.1134/S1070363220090030

upstream raw materials:

Indole-3-carboxaldehyde

phenylhydrazine

4-fluorophenylhydrazine

Downstream raw materials:

C₂₂H₁₉N₅

C₂₃H₂₁N₅O

1-phenyl-3-(3'-indole)-5-phenyl formazan

3-Chloro-4-(1H-indol-3-yl)-1-phenylamino-azetidin-2-one

Refernces

• 1、 Suryawanshi, Sonali B.,Desai, Netaji K.,Bodake, Anita J.,Patil, Shivajirao R.. "Fluorescence Enhancement Based Quantification of Human Serum Albumin from Biological Sample Using Indole Based Nanosuspension: Molecular Interactions and Molecular Docking Studies". . p. 293 - 305. Retrieved 2021/11/18.
• 2、 Purgatorio, Rosa,Gambacorta, Nicola,Catto, Marco,de Candia, Modesto,Pisani, Leonardo,Espargaró, Alba,Sabaté, Raimon,Cellamare, Saverio,Nicolotti, Orazio,Altomare, Cosimo D.. "Pharmacophore modeling and 3D-QSAR study of indole and isatin derivatives as antiamyloidogenic agents targeting Alzheimer’s disease". . . Retrieved 2021/01/12.