2-(1,4-dioxaspiro[4.5]decan-8-yl)-1,2,3,4-tetrahydroisoquinoline

Base Information

• Chemical Name: 2-(1,4-dioxaspiro[4.5]decan-8-yl)-1,2,3,4-tetrahydroisoquinoline
• CAS No.: 166398-22-7
• Molecular Formula: C17H23NO2
• Molecular Weight: 273.37000
• Mol file: 166398-22-7.mol

Synonyms:8-(Tetrahydroisoquinolin-2-yl)-1,4-dioxaspiro[4,5]decane;Isoquinoline,2-(1,4-dioxaspiro[4.5]dec-8-yl)-1,2,3,4-tetrahydro;2-(1,4-Dioxaspiro[4.5]dec-8-yl)-1,2,3,4-tetrahydroisoquinoline;

Chemical Property of 2-(1,4-dioxaspiro[4.5]decan-8-yl)-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

• PSA: 21.70000
• Density: 1.17
• LogP: 2.66830

Purity/Quality:

99% ^*data from raw suppliers

2-(1,4-Dioxaspiro[4.5]dec-8-yl)-1,2,3,4-tetrahydroisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(1,4-dioxaspiro[4.5]decan-8-yl)-1,2,3,4-tetrahydroisoquinoline

There total 1 articles about 2-(1,4-dioxaspiro[4.5]decan-8-yl)-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,3,4-tetrahydroisoquinoline (91-21-4) + cyclohexanedione monoethylene ketal (4746-97-8) → 8-(Tetrahydroisoquinolin-2-yl)-1,4-dioxaspiro[4,5]decane (166398-22-7)

Guidance literature:

1,2,3,4-tetrahydroisoquinoline; cyclohexanedione monoethylene ketal; With 1,2,3-Benzotriazole; In benzene; for 2h; Heating;

With sodium tetrahydroborate; In tetrahydrofuran; for 3h; Heating;

DOI:10.1021/jm991045h

Reference yield:

8-(Tetrahydroisoquinolin-2-yl)-1,4-dioxaspiro[4,5]decane (166398-22-7) → 4-[2-(1,2,3,4-tetrahydroisoquinolinyl)]cyclohexanone (166398-23-8)

Guidance literature:

With hydrogenchloride; In acetone; at 20 ℃;

DOI:10.1021/jm991045h

upstream raw materials:

1,2,3,4-tetrahydroisoquinoline

cyclohexanedione monoethylene ketal

Downstream raw materials:

4-[2-(1,2,3,4-tetrahydroisoquinolinyl)]cyclohexanone

Refernces

• 1、 -. "Spirocycles". . . Retrieved 2008/06/13.