N,N-diethyl-2,3-dimethoxybenzamide

Base Information

• Chemical Name: N,N-diethyl-2,3-dimethoxybenzamide
• CAS No.: 30577-84-5
• Molecular Formula: C13H19 N O3
• Molecular Weight: 237.299
• Mol file: 30577-84-5.mol

Synonyms:o-Veratramide,N,N-diethyl- (8CI); 2,3-Dimethoxy-N,N-diethylbenzamide;N,N-Diethyl-2,3-dimethoxybenzamide; NSC 404091

Chemical Property of N,N-diethyl-2,3-dimethoxybenzamide

Chemical Property:

• Vapor Pressure: 5.54E-06mmHg at 25°C
• Boiling Point: 380.2°C at 760 mmHg
• Flash Point: 183.7°C
• Density: 1.051g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-diethyl-2,3-dimethoxybenzamide

There total 8 articles about N,N-diethyl-2,3-dimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

O-(2-N,N-diethylcarbamoyloxy)phenyl N,N-diethylcarbamate (101270-37-5) + methyl iodide (74-88-4) → N,N-diethyl-2,3-dimethoxybenzamide (30577-84-5) + C18H28N2O4

Guidance literature:

O-(2-N,N-diethylcarbamoyloxy)phenyl N,N-diethylcarbamate; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

methyl iodide; In tetrahydrofuran; Inert atmosphere;

DOI:10.1002/ejoc.201701143

Reference yield:

diethylamine (109-89-7) + 2,3-dimethoxybenzoyl chloride (7169-06-4) → N,N-diethyl-2,3-dimethoxybenzamide (30577-84-5)

Guidance literature:

DOI:10.1021/jo01369a003

Reference yield:

2,3-dimethoxybenzoic acid (1521-38-6) → N,N-diethyl-2,3-dimethoxybenzamide (30577-84-5)

Guidance literature:

Multi-step reaction with 2 steps

1: DMF; oxalyl chloride / CH₂Cl₂ / 1 h

2: 5.7 g / CH₂Cl₂ / -45 °C

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/jm025553u

upstream raw materials:

diethylamine

2,3-dimethoxybenzoyl chloride

N,N-diethyl-1-carbamyloxy-2-methoxybenzene

N,N-diethylcarbamyl chloride

Downstream raw materials:

N,N-diethyl 2-iodo-5,6-dimethoxy-benzamide

N,N-diethyl-3-methoxybenzamide

N,N-diethyl-2,3-dimethoxy-6-(2-methylallyl)benzamide

N,N-Diethyl-2,3-dimethoxy-6-sulfamoyl-benzamide