[1,1'-Biphenyl]-2-sulfonamide, 4'-[[1,5-dihydro-3-[(2-methylcyclopropyl)methyl]-5-oxo-1-[2-(trifluorometh yl)phenyl]-4H-1,2,4-triazol-4-yl]methyl]-N-(1,1-dimethylethyl)-

Base Information

• Chemical Name: [1,1'-Biphenyl]-2-sulfonamide, 4'-[[1,5-dihydro-3-[(2-methylcyclopropyl)methyl]-5-oxo-1-[2-(trifluorometh yl)phenyl]-4H-1,2,4-triazol-4-yl]methyl]-N-(1,1-dimethylethyl)-
• CAS No.: 169599-01-3
• Molecular Formula: C31H33F3N4O3S
• Molecular Weight: 598.689

Synonyms:

Chemical Property of [1,1'-Biphenyl]-2-sulfonamide, 4'-[[1,5-dihydro-3-[(2-methylcyclopropyl)methyl]-5-oxo-1-[2-(trifluorometh yl)phenyl]-4H-1,2,4-triazol-4-yl]methyl]-N-(1,1-dimethylethyl)-

Chemical Property:

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Useful:

Technology Process of [1,1'-Biphenyl]-2-sulfonamide, 4'-[[1,5-dihydro-3-[(2-methylcyclopropyl)methyl]-5-oxo-1-[2-(trifluorometh yl)phenyl]-4H-1,2,4-triazol-4-yl]methyl]-N-(1,1-dimethylethyl)-

There total 2 articles about [1,1'-Biphenyl]-2-sulfonamide, 4'-[[1,5-dihydro-3-[(2-methylcyclopropyl)methyl]-5-oxo-1-[2-(trifluorometh yl)phenyl]-4H-1,2,4-triazol-4-yl]methyl]-N-(1,1-dimethylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2,4-dihydro-5-[(2-methylcylopropyl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one + dichloromethane (75-09-2) + [[2'-[(t-Butylamino)sulfonyl]-1,1'-biphenyl-4-yl]methyl] bromide (138733-52-5) → 4-[[2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl]-2,4-dihydro-5-[(2-methylcyclopropyl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (169599-01-3)

Guidance literature:

In methanol;

Reference yield:

[[2'-[(t-Butylamino)sulfonyl]-1,1'-biphenyl-4-yl]methyl] bromide (138733-52-5) + 5-(2-Methyl-cyclopropylmethyl)-2-(2-trifluoromethyl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one → 4-[[2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl]-2,4-dihydro-5-[(2-methylcyclopropyl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (169599-01-3)

Guidance literature:

With sodium hydride; Multistep reaction; 1.) DMF, 50 deg C, 1 h, 2.) DMF, 50 deg C, 1.5 h;

DOI:10.1021/jm00043a020

Reference yield:

4-[[2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl]-2,4-dihydro-5-[(2-methylcyclopropyl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (169599-01-3) → 2,4-dihydro-5-[(2-methylcyclopropyl)methyl]-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (169599-02-4)

Guidance literature:

With methoxybenzene; trifluoroacetic acid; Ambient temperature;

DOI:10.1021/jm00043a020

upstream raw materials:

[[2'-[(t-Butylamino)sulfonyl]-1,1'-biphenyl-4-yl]methyl] bromide

dichloromethane

Downstream raw materials:

2,4-dihydro-5-[(2-methylcyclopropyl)methyl]-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one

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