6-Ethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-one

Base Information

Chemical Name:6-Ethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-one
CAS No.:170466-84-9
Molecular Formula:C15H13NO3S
Molecular Weight:287.33400
Hs Code.:
DSSTox Substance ID:DTXSID60419816
Nikkaji Number:J3.436.835J
Pharos Ligand ID:FLML1CZRFRLA
ChEMBL ID:CHEMBL1380622
Mol file:170466-84-9.mol

Synonyms:170466-84-9;6-Ethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-one;TimTec1_005381;Oprea1_267616;Oprea1_549325;MLS000713555;CHEMBL1380622;DTXSID60419816;HMS1549E13;HMS2755J17;6-ethyl-7-hydroxy-3-(4-methyl(1,3-thiazol-2-yl))chromen-4-one;MFCD00181417;AKOS000267941;SMR000273036;CS-0336883;SR-01000401340;SR-01000401340-1;3-(4-Methyl-2-thiazolyl)-6-ethyl-7-hydroxychromone;6-ethyl-7-hydroxy-3-(4-methyl-1,3-thiazol-2-yl)-4H-chromen-4-one

Suppliers and Price of 6-Ethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
6-Ethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-one 97%
1g
$ 307.00

Crysdot
6-Ethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-one 97%
5g
$ 837.00

Crysdot
6-Ethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-one 97%
10g
$ 1280.00

Chemenu
6-Ethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-one 97%
10g
$ 1206.00

Chemenu
6-Ethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-one 97%
5g
$ 790.00

Chemenu
6-Ethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-one 97%
1g
$ 290.00

Total 3 raw suppliers

Chemical Property of 6-Ethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-one

Chemical Property:

Boiling Point:488.8±55.0 °C(Predicted)
PKA:6.85±0.20(Predicted)
PSA：91.57000
Density:1.371±0.06 g/cm3(Predicted)
LogP:3.49290
XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:287.06161445
Heavy Atom Count:20
Complexity:425

Purity/Quality:

99% ^*data from raw suppliers

6-Ethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-one 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1=CC2=C(C=C1O)OC=C(C2=O)C3=NC(=CS3)C

Technology Process of 6-Ethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-one

There total 5 articles about 6-Ethyl-7-hydroxy-3-(4-methylthiazol-2-yl)-4H-chromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 170466-78-1
1-(2,4-dihydroxy-5-ethylphenyl)-2-(4-methyl-1,3-thiazol-2-yl)ethanone

: 2258-42-6
formyl acetic anhydride

: 170466-84-9
6-ethyl-7-hydroxy-3-(4-methyl-1,3-thiazol-2-yl)-4H-chromen-4-one

Guidance literature:: at 80 - 100 ℃; for 1.5h;
DOI:10.1007/BF01177015

Reference yield: 40.0%

: 170466-78-1
1-(2,4-dihydroxy-5-ethylphenyl)-2-(4-methyl-1,3-thiazol-2-yl)ethanone

: 170466-84-9
6-ethyl-7-hydroxy-3-(4-methyl-1,3-thiazol-2-yl)-4H-chromen-4-one

Guidance literature:: With piperidine; pyridine; orthoformic acid triethyl ester; at 70 - 80 ℃; for 4h;
DOI:10.1039/c3md00338h

Reference yield:

: 2896-60-8
4-ethyl-1,3-benzenediol

: 19785-39-8
(4-methylthiazol-2-yl)acetonitrile

: 170466-84-9
6-ethyl-7-hydroxy-3-(4-methyl-1,3-thiazol-2-yl)-4H-chromen-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: boron trifluoride diethyl etherate / diethyl ether / 0.17 h / 25 - 27 °C

1.2: 6 h / 30 - 40 °C

2.1: orthoformic acid triethyl ester; pyridine; piperidine / 4 h / 70 - 80 °C

With piperidine; pyridine; boron trifluoride diethyl etherate; orthoformic acid triethyl ester; In diethyl ether;
DOI:10.1039/c3md00338h