2896-60-8

Basic information

• Product Name: 4-Ethylresorcinol
• Synonyms: 1,3-Dihydroxy-4-ethylbenzene;4-ethyl-3-benzenediol;6-Ethylresorcinol;Ethyl 1,3-benzenediol;Resorcinol, 4-ethyl-;2,4-dihydroxy-1-ethylbenzene;2,4-DIHYDROXYETHYLBENZENE;4-ETHYL-1,3-BENZENEDIOL
• CAS NO: 2896-60-8
• Molecular Formula: C₈H₁₀O₂
• Molecular Weight: 138.16
• EINECS: 220-777-1
• Product Categories: Aromatic Phenols;Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Polyols;Building block
• Mol File: 2896-60-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 95-98 °C(lit.)
• Boiling Point: 155 °C / 10mmHg
• Flash Point: 134.4 °C
• Appearance: Slightly beige/Crystalline Powder
• Density: 1.0742 (rough estimate)
• Vapor Pressure: 0.00336mmHg at 25°C
• Refractive Index: 1.5231 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Solubility in methanol; almost transparency. Soluble in alcohol.
• PKA: 10.06±0.10(Predicted)
• BRN: 1238231
• CAS DataBase Reference: 4-Ethylresorcinol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Ethylresorcinol(2896-60-8)
• EPA Substance Registry System: 4-Ethylresorcinol(2896-60-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39-36
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 2896-60-8(Hazardous Substances Data)

Usage

Chemical Properties

slightly beige crystalline powder

Uses

It is employed as an active pharmaceutical intermediate.

Synthesis Reference(s)

Synthetic Communications, 15, p. 1315, 1985 DOI: 10.1080/00397918508077280

Synthesis

The synthesis of 4-Ethylresorcinol is as follows:In a three necked round bottom flask (equipped with a condensor, additional funnel and mechanical stirrer) was added 15.2 g of a combination of Raney Nickel and Ni supported on silica. (50: 50). 100 ml of a mixture of 50: 50 ethanol: water was added and the reaction was heated at reflux conditions. 15.2 g of 2,4-dihydroxy acetophenone in 100 ml of water: ethanol and 10 ml of acetic acid was placed in the additional funnel and slowly added to the mixture (dropwise). The reaction was filtered through a milipore filter to give a pale yellow solution. Concentration of this solution in vacuo gave a solid. This solid was crystalized from 1,2-dichloroethane to give 4-ethyl resorcinol in 80% isolated yield.

InChI:InChI=1/C8H10O2/c1-2-6-3-4-7(9)5-8(6)10/h3-5,9-10H,2H2,1H3

Upstream product

• 960601-99-4 4-ethyl-1,3-di-O-propanoyl-resorcinol 
• 42059-48-3 acetic acid 4-acetyl-3-hydroxyphenyl ester 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 52751-42-5 2'-acetoxy-4'-hydroxyacetophenone 
• 72712-19-7 2,4-diacetoxy acetophenone 
• 6626-15-9 4-Bromoresorcinol 
• 108-46-3 recorcinol 
• 7647-01-0 hydrogenchloride 
• 5330-85-8 2-butoxy-1-(2,4-dihydroxy-phenyl)-ethanone 
• 60965-25-5 5'-bromo-2',4'-dihydroxyacetophenone 
• 106209-27-2 4-ethenyl-1,3-benzenediol 
• 54337-59-6 3'-ethyl-2',6'-dihydroxyacetophenone 
• 2163-12-4 2,4-diacetylresorcinol 
• 100-41-4 ethylbenzene 

Downstream Products

• 136498-55-0 α-(1,4-benzodioxan-6-yl)-2,4-dihydroxy-5-ethylacetophenone 
• 960601-99-4 4-ethyl-1,3-di-O-propanoyl-resorcinol 
• 328018-52-6 1-(5-ethyl-2,4-dihydroxy-phenyl)-2-(4-fluoro-phenyl)-ethanone 
• 37470-83-0 5-ethyl-2,4-dihydroxy-benzaldehyde 
• 339529-92-9 5-benzyloxy-2-ethyl-4-pyrrol-1-yl-phenol 
• 80761-82-6 α-(2-Methyl-4-thiazolyl)-2,4-dihydroxy-5-ethylacetophenone 
• 134626-67-8 1-(5-Ethyl-2,4-dihydroxy-phenyl)-2-isoxazol-3-yl-ethanone 
• 134785-33-4 bis(2,4-dihydroxy-5-ethyl-1-phenyl)(2-pyridyl)methane 
• 859184-90-0 2-(4-ethyl-3-hydroxy-phenoxy)-ethanol 
• 859777-27-8 1,3-bis(2-hydroxyethoxy)-4-ethylbenzene 
• 4460-42-8 1-(5-ethyl-2,4-dihydroxyphenyl)ethanone 
• 19672-03-8 1-ethyl-2,4-dimethoxybenzene 
• 58926-60-6 2-ethyl-3-hydroxy-7,8,9,10-tetrahydro-benzo[c]chromen-6-one 
• 874520-34-0 1-(5-ethyl-2,4-dihydroxy-phenyl)-2-chloro-ethanone 

Relevant articles and documents

Structural features and antioxidant activities of Chinese quince (Chaenomeles sinensis) fruits lignin during auto-catalyzed ethanol organosolv pretreatment

Chinese quince fruits (Chaenomeles sinensis) have an abundance of lignins with antioxidant activities. To facilitate the utilization of Chinese quince fruits, lignin was isolated from it by auto-catalyzed ethanol organosolv pretreatment. The effects of three processing conditions (temperature, time, and ethanol concentration) on yield, structural features and antioxidant activities of the auto-catalyzed ethanol organosolv lignin samples were assessed individually. Results showed the pretreatment temperature was the most significant factor; it affected the molecular weight, S/G ratio, number of β-O-4′ linkages, thermal stability, and antioxidant activities of lignin samples. According to the GPC analyses, the molecular weight of lignin samples had a negative correlation with pretreatment temperature. 2D-HSQC NMR and Py-GC/MS results revealed that the S/G ratios of lignin samples increased with temperature, while total phenolic hydroxyl content of lignin samples decreased. The structural characterization clearly indicated that the various pretreatment conditions affected the structures of organosolv lignin, which further resulted in differences in the antioxidant activities of the lignin samples. These results can be helpful for controlling and optimizing delignification during auto-catalyzed ethanol organosolv pretreatment, and they provide theoretical support for the potential applications of Chinese quince fruits lignin as a natural antioxidant in the food industry.

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PROCESS FOR THE PREPARATION OF A COSMETIC ACTIVE

A process for the preparation of a compound of formula (I) wherein R is a hydrogen or a C1-6 alkyl group which is straight chain, branched or cyclic, with or without an oxygen, nitrogen or sulphur heteroatom anywhere in the chain or ring by reacting a compound of formula (II) with a source of hydrogen selected from either hydrogen or water in the presence of a mixture of at least two catalysts selected from nickel, raney nickel, and palladium, at a pH below 7.0 in a solvent medium comprising an alcohol having a carbon chain length of up to 3.