2-(4-Methoxyphenyl)-5-phenyloxazole

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)-5-phenyloxazole
• CAS No.: 17064-22-1
• Molecular Formula: C16H13NO2
• Molecular Weight: 251.285
• DSSTox Substance ID: DTXSID40355389
• Nikkaji Number: J1.064.238H
• Wikidata: Q82134257
• Mol file: 17064-22-1.mol

Synonyms:2-(4-METHOXYPHENYL)-5-PHENYLOXAZOLE;17064-22-1;2-(4-methoxyphenyl)-5-phenyl-1,3-oxazole;Oxazole, 2-(4-methoxyphenyl)-5-phenyl-;Cambridge id 6872661;Oprea1_799369;SCHEMBL4875222;DTXSID40355389;ZAQGDEAUNXUCQP-UHFFFAOYSA-N;2-(4-Methoxyphenyl)-5-phenyloxazol;2-(p-methoxyphenyl)-5-phenyl-1,3-oxazole;SR-01000245172;SR-01000245172-1

Chemical Property of 2-(4-Methoxyphenyl)-5-phenyloxazole

Chemical Property:

• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 251.094628657
• Heavy Atom Count: 19
• Complexity: 270

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=NC=C(O2)C3=CC=CC=C3

Technology Process of 2-(4-Methoxyphenyl)-5-phenyloxazole

There total 31 articles about 2-(4-Methoxyphenyl)-5-phenyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

p-methoxyl benzaldoxime (3717-21-3,3717-22-4,140461-28-5,140461-29-6,3235-04-9) + phenylacetylene (536-74-3) → 2-(4-methoxyphenyl)-5-phenyl oxazole (17064-22-1)

Guidance literature:

p-methoxyl benzaldoxime; With trifluorormethanesulfonic acid; silica gel; In toluene; at 50 ℃; for 0.5h;

phenylacetylene; In toluene; at 70 ℃; for 3.5h;

With copper(II) choride dihydrate; lithium chloride hydrate; oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,4-dioxane; propan-1-ol; toluene; at 60 ℃; for 4h; under 9750.98 Torr;

DOI:10.1002/jhet.1637

Reference yield: 90.0%

C17H13NO4 → 2-(4-methoxyphenyl)-5-phenyl oxazole (17064-22-1)

Guidance literature:

With fac-tris(2-phenylpyridinato-N,C₂')iridium(III); In 1,4-dioxane; at 20 ℃; for 3h; Inert atmosphere; Irradiation;

DOI:10.1021/acs.orglett.9b00903

Reference yield: 84.0%

trans-[3-(4-methoxy-phenyl)-aziridin-2-yl]-phenyl-methanone → 2-(4-methoxyphenyl)-5-phenyl oxazole (17064-22-1)

Guidance literature:

With iodine; dicyclohexyl-carbodiimide; In acetonitrile; for 2h; Reflux;

DOI:10.1055/s-0032-1317925

upstream raw materials:

4-methoxy-N-(2-oxo-2-phenylethyl)benzamide

(RS)-mandelonitrile

4-methoxy-benzaldehyde

para-iodoanisole

Downstream raw materials:

2-(p-hydroxyphenyl)-5-phenyloxazole

3-(4-methoxyphenyl)-5-phenylisoxazole

4-(4-methoxy-phenyl)-5-phenyl-oxazole