L-Tyrosine, O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: L-Tyrosine, O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester
• CAS No.: 17083-17-9
• Molecular Formula: C25H33NO5
• Molecular Weight: 427.53300

Synonyms:O-tert.-Butyl-N-benzyloxycarbonyl-L-tyrosin-tert.-butylester;(S)-2-Benzyloxycarbonylamino-3-(4-tert-butoxy-phenyl)-propionic acid tert-butyl ester;Z-L-Tyr(t-Bu)-O-t-Bu;

Chemical Property of L-Tyrosine, O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester

Chemical Property:

• PSA: 73.86000
• LogP: 5.43400

Purity/Quality:

99% ,98%,Electron Grade , ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Tyrosine, O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester

There total 3 articles about L-Tyrosine, O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

Z-L-Tyr-OH (1164-16-5) + isobutene (115-11-7,15220-85-6) → O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-L-tyrosine 1,1-dimethylethyl ester (17083-17-9)

Guidance literature:

With sulfuric acid; In dichloromethane; for 168h;

Reference yield:

N-[(phenylmethoxy)carbonyl]-L-tyrosine (16679-94-0) → O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-L-tyrosine 1,1-dimethylethyl ester (17083-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent

2: 74 percent / conc.H₂SO₄ / CH₂Cl₂ / 168 h

With sulfuric acid; In dichloromethane;

Reference yield:

L-tyrosine ethyl ester monohydrochloride (4089-07-0) → O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-L-tyrosine 1,1-dimethylethyl ester (17083-17-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent

2: 89 percent

3: 74 percent / conc.H₂SO₄ / CH₂Cl₂ / 168 h

With sulfuric acid; In dichloromethane;

upstream raw materials:

Z-L-Tyr-OH

isobutene

N-[(phenylmethoxy)carbonyl]-L-tyrosine

L-tyrosine ethyl ester monohydrochloride

Downstream raw materials:

(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propionic acid tert-butyl ester

Adpoc-L-Val-L-Tyr(t-Bu)-O-t-Bu

Z-L-Asp(O-t-Bu)-L-Val-L-Tyr(t-Bu)-O-t-Bu

Adpoc-L-Lys(Boc)-L-Asp(O-t-Bu)-L-Val-L-Tyr(t-Bu)-O-t-Bu

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