Technology Process of Propanoic acid, 2-[(phenylmethoxy)methoxy]-, methyl ester, (2S)-
There total 9 articles about Propanoic acid, 2-[(phenylmethoxy)methoxy]-, methyl ester, (2S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2S,5R,3E)-2-(Benzyloxymethoxy)-6-methyl-5-(benzyloxycarbonylamino)hept-3-ene;
With
ozone;
In
methanol;
at -78 ℃;
for 0.333333h;
With
dimethylsulfide;
In
methanol;
at -78 - 20 ℃;
for 1h;
methanol;
With
water; bromine; sodium hydrogencarbonate;
at 20 ℃;
Title compound not separated from byproducts;
DOI:10.1039/a905772b
- Guidance literature:
-
With
sodium hydroxide;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
Cooling with ice;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
1.2: 90 percent / tetrahydrofuran; hexane / 2 h / -78 °C
2.1: LiCl; DBU / acetonitrile / 20 h
3.1: Zn(BH4)2 / diethyl ether / 2.5 h / -35 °C
4.1: BuLi / tetrahydrofuran / 0.25 h / 0 °C
4.2: tetrahydrofuran / 1 h / -78 °C
5.1: 91 percent / xylene / 4 h / Heating
6.1: Ba(OH)2 / methanol / 20 °C
7.1: KHCO3 / ethyl acetate; H2O / 20 °C
8.1: O3 / methanol / 0.33 h / -78 °C
8.2: Me2S / methanol / 1 h / -78 - 20 °C
8.3: 73 percent / Br2; NaHCO3; H2O / 20 °C
With
barium dihydroxide; n-butyllithium; zinc(II) tetrahydroborate; potassium hydrogencarbonate; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride;
In
tetrahydrofuran; methanol; diethyl ether; hexane; water; ethyl acetate; acetonitrile; xylene;
1.1: Metallation / 1.2: Acylation / 2.1: Condensation / 3.1: Reduction / 4.1: Metallation / 4.2: Addition / 5.1: Rearrangement / 6.1: Deacylation / 7.1: Acylation / 8.1: Oxidation / 8.2: Reduction / 8.3: Oxidation;
DOI:10.1039/a905772b
