Benzenebutanal, 2-iodo-

Base Information

• Chemical Name: Benzenebutanal, 2-iodo-
• CAS No.: 171734-11-5
• Molecular Formula: C10H11IO
• Molecular Weight: 274.101
• Mol file: 171734-11-5.mol

Synonyms:

Chemical Property of Benzenebutanal, 2-iodo-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenebutanal, 2-iodo-

There total 7 articles about Benzenebutanal, 2-iodo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-(2-Iodophenyl)-1-methoxybut-1-ene → 4-(2-Iodophenyl)butanal (171734-11-5)

Guidance literature:

With formic acid; In dichloromethane; for 30h; Ambient temperature;

Reference yield: 95.0%

4-(o-iodophenyl)butan-1-ol (1093413-28-5) → 4-(2-Iodophenyl)butanal (171734-11-5)

Guidance literature:

4-(o-iodophenyl)butan-1-ol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.5h;

With triethylamine; In dichloromethane; at -78 - 20 ℃;

DOI:10.1021/ol2003308

Reference yield:

ethyl 4-(2-iodophenyl)butanoate (1271193-41-9) → 4-(2-Iodophenyl)butanal (171734-11-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / -50 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C

2.2: -78 - 20 °C

With oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/ol2003308

upstream raw materials:

4-(o-iodophenyl)butan-1-ol

ethyl 4-(2-iodophenyl)butanoate

2-(2-iodophenyl)ethan-1-ol

1-iodo-2-(2-iodoethyl)-benzene

Downstream raw materials:

N-<4-(2-Iodophenyl)butyl>serine methyl ester

2-(4-(2-iodophenyl)butyl)-3-oxocyclohex-1-enyl trifluoromethanesulfonate

Refernces

• 1、 Gibson, Susan E.,Guillo, Nathalie,Middleton, Richard J.,Thuilliez, Audrey,Tozer, Matthew J.. "Synthesis of conformationally constrained phenylalanine analogues via 7-, 8- and 9-endo Heck cyclisations". . p. 447 - 455. Retrieved 2007/10/03.