1-(4-Chloro-1,2,5-thiadiazol-3-yl)piperidine

Base Information

• Chemical Name: 1-(4-Chloro-1,2,5-thiadiazol-3-yl)piperidine
• CAS No.: 173053-54-8
• Molecular Formula: C7H10ClN3S
• Molecular Weight: 203.69200
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID30355616
• Wikidata: Q82134624
• Mol file: 173053-54-8.mol

Synonyms:1-(4-chloro-1,2,5-thiadiazol-3-yl)piperidine;173053-54-8;3-chloro-4-piperidin-1-yl-1,2,5-thiadiazole;3-Chloro-4-(piperidin-1-yl)-1,2,5-thiadiazole;1-(4-Chloro-[1,2,5]thiadiazol-3-yl)-piperidine;BAS 01862950;SCHEMBL8806823;DTXSID30355616;BBL029547;MFCD02050619;STK504177;AKOS000266397;VS-09291;CS-0215514;EN300-255660;F2167-4643

Chemical Property of 1-(4-Chloro-1,2,5-thiadiazol-3-yl)piperidine

Chemical Property:

• PSA: 57.26000
• LogP: 2.24680
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 203.0283962
• Heavy Atom Count: 12
• Complexity: 152

Purity/Quality:

97% ^*data from raw suppliers

1-(4-chloro-1,2,5-thiadiazol-3-yl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C2=NSN=C2Cl

Technology Process of 1-(4-Chloro-1,2,5-thiadiazol-3-yl)piperidine

There total 3 articles about 1-(4-Chloro-1,2,5-thiadiazol-3-yl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

piperidine (110-89-4) + 3,4-dichloro-1,2,5-thiadiazole (5728-20-1) → 3-(piperidin-1-yl)-4-chloro-1,2,5-thiadiazole (173053-54-8)

Guidance literature:

at 110 - 120 ℃;

DOI:10.1002/cmdc.201402453

Reference yield: 30.0%

piperidineglyoxime (871918-91-1) → 3-(piperidin-1-yl)-4-chloro-1,2,5-thiadiazole (173053-54-8)

Guidance literature:

With pyridine; disulfur dichloride; In acetonitrile; at -30 - 82 ℃; for 24h;

DOI:10.1007/s11172-016-1635-1

Reference yield:

→ 3-(piperidin-1-yl)-4-chloro-1,2,5-thiadiazole (173053-54-8)

Guidance literature:

upstream raw materials:

piperidine

3,4-dichloro-1,2,5-thiadiazole

piperidineglyoxime

Downstream raw materials:

3-hydroxy-4-(piperidin-1-yl)-1,2,5-thiadiazole

4-(piperidin-1-yl)-1,2,5-thiadiazol-3-yl morpholine-4-carboxylate