Cyclohexanone, 4-(1-hydroxy-1-methylethyl)-

Base Information

• Chemical Name: Cyclohexanone, 4-(1-hydroxy-1-methylethyl)-
• CAS No.: 17328-67-5
• Molecular Formula: C9H16O2
• Molecular Weight: 156.225
• Mol file: 17328-67-5.mol

Synonyms:

Chemical Property of Cyclohexanone, 4-(1-hydroxy-1-methylethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexanone, 4-(1-hydroxy-1-methylethyl)-

There total 6 articles about Cyclohexanone, 4-(1-hydroxy-1-methylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

ethyl 4-oxocyclohexane-1-carboxylate (17159-79-4) + methylmagnesium bromide (75-16-1) → 4-(2-hydroxypropan-2-yl)cyclohexanone (17328-67-5)

Guidance literature:

ethyl 4-oxocyclohexane-1-carboxylate; With n-butyllithium; trimethylaluminum; N,O-dimethylhydroxylamine*hydrochloride; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 2h;

methylmagnesium bromide; In tetrahydrofuran; diethyl ether; hexane; at 0 - 20 ℃; for 1h;

DOI:10.1021/ol401265a

Reference yield: 60.0%

4-isopropyl-cyclohexanone (5432-85-9) → 4-(2-hydroxypropan-2-yl)cyclohexanone (17328-67-5) + 1'-fluoro-4-isopropylcyclohexanone (177995-52-7)

Guidance literature:

With tetrachloromethane; hydrogen fluoride; antimony pentafluoride; at -30 ℃; for 0.0333333h;

DOI:10.1016/0040-4039(96)00475-3

Reference yield:

(1R,5S)-(+)-nopinone (38651-65-9) → 4-(2-hydroxypropan-2-yl)cyclohexanone (17328-67-5)

Guidance literature:

With sulfuric acid;

upstream raw materials:

4-hydroxycyclohexyl carboxylic acid ethyl ester

methyllithium

(1R,5S)-(+)-nopinone

4-isopropyl-cyclohexanone

Refernces

• 1、 Barrios, Francis J.,Springer, Brannon C.,Colby, David A.. "Control of transient aluminum-aminals for masking and unmasking reactive carbonyl groups". supporting information. p. 3082 - 3085. Retrieved 2013/07/26.
• 2、 -. "COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY". Page/Page column 100. . Retrieved 2010/11/23.