Silane, (1,1-dimethylethyl)[4-[7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-(4-fluoro phenyl)-2H-1-benzopyran-3-yl]phenoxy]dimethyl-

Base Information

• Chemical Name: Silane, (1,1-dimethylethyl)[4-[7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-(4-fluoro phenyl)-2H-1-benzopyran-3-yl]phenoxy]dimethyl-
• CAS No.: 173676-37-4
• Molecular Formula: C33H43FO3Si2
• Molecular Weight: 562.872
• Mol file: 173676-37-4.mol

Synonyms:

Chemical Property of Silane, (1,1-dimethylethyl)[4-[7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-(4-fluoro phenyl)-2H-1-benzopyran-3-yl]phenoxy]dimethyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Silane, (1,1-dimethylethyl)[4-[7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-(4-fluoro phenyl)-2H-1-benzopyran-3-yl]phenoxy]dimethyl-

There total 5 articles about Silane, (1,1-dimethylethyl)[4-[7-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-(4-fluoro phenyl)-2H-1-benzopyran-3-yl]phenoxy]dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-flourophenylmagnesium bromide (352-13-6) + 7-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-phenoxy-2H-chromene (173676-53-4) → 7-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-(4-fluoro-phenyl)-2H-chromene (173676-37-4)

Guidance literature:

In toluene; 0 deg C to RT;

DOI:10.1016/0040-4039(95)01916-6

Reference yield:

7-methoxy-3-(4-methoxyphenyl)-2H-chromen-2-one (3173-00-0) → 7-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-(4-fluoro-phenyl)-2H-chromene (173676-37-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) EtSH, AlCl₃, 2.) Et₃N / 1.) CH₂Cl₂, 2.) CH₂Cl₂

2: 83 percent / DIBAL-H / toluene / -78 °C

3: 97 percent / chlorobenzene / Heating

4: 77 percent / toluene / 0 deg C to RT

With aluminium trichloride; diisobutylaluminium hydride; triethylamine; ethanethiol; In chlorobenzene; toluene;

DOI:10.1016/0040-4039(95)01916-6

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 7-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-(4-fluoro-phenyl)-2H-chromene (173676-37-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) EtSH, AlCl₃, 2.) Et₃N / 1.) CH₂Cl₂, 2.) CH₂Cl₂

2: 83 percent / DIBAL-H / toluene / -78 °C

3: 97 percent / chlorobenzene / Heating

4: 77 percent / toluene / 0 deg C to RT

With aluminium trichloride; diisobutylaluminium hydride; triethylamine; ethanethiol; In chlorobenzene; toluene;

DOI:10.1016/0040-4039(95)01916-6

upstream raw materials:

4-flourophenylmagnesium bromide

7-(tert-Butyl-dimethyl-silanyloxy)-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-phenoxy-2H-chromene

7-methoxy-3-(4-methoxyphenyl)-2H-chromen-2-one

tert-butyldimethylsilyl chloride