Carbamic acid, [3-[cyclopropyl[6-[2-cyclopropyl-1-(cyclopropylmethyl)ethyl]-4-hydroxy-2- oxo-2H-pyran-3-yl]methyl]phenyl]-, phenylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [3-[cyclopropyl[6-[2-cyclopropyl-1-(cyclopropylmethyl)ethyl]-4-hydroxy-2- oxo-2H-pyran-3-yl]methyl]phenyl]-, phenylmethyl ester
• CAS No.: 174485-01-9
• Molecular Formula: C32H35NO5
• Molecular Weight: 513.634
• Mol file: 174485-01-9.mol

Synonyms:

Chemical Property of Carbamic acid, [3-[cyclopropyl[6-[2-cyclopropyl-1-(cyclopropylmethyl)ethyl]-4-hydroxy-2- oxo-2H-pyran-3-yl]methyl]phenyl]-, phenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [3-[cyclopropyl[6-[2-cyclopropyl-1-(cyclopropylmethyl)ethyl]-4-hydroxy-2- oxo-2H-pyran-3-yl]methyl]phenyl]-, phenylmethyl ester

There total 7 articles about Carbamic acid, [3-[cyclopropyl[6-[2-cyclopropyl-1-(cyclopropylmethyl)ethyl]-4-hydroxy-2- oxo-2H-pyran-3-yl]methyl]phenyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopropyl phenyl ketone (3481-02-5) → 3-(α-cyclopropyl-meta-(tert-butyloxycarbonylamino)benzyl)-6-(α-cyclopropylmethyl-cyclopropylethyl)-4-hydroxy-2H-pyran-2-one (174485-01-9)

Guidance literature:

Multi-step reaction with 5 steps

1: nitric acid / water / -40 - -10 °C / Cooling with acetone-dry ice

2: hydrogen / 5% platinum on charcoal / methanol / 5 h / 760.05 Torr

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 20 °C

4: sodium tetrahydroborate / tetrahydrofuran; ethanol / 3 h / 20 °C

5: toluene-4-sulfonic acid / benzene / Heating / reflux

With sodium tetrahydroborate; hydrogen; nitric acid; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; 5% platinum on charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; benzene;

Reference yield:

cyclopropyl-(3-nitrophenyl)methanone (5680-51-3) → 3-(α-cyclopropyl-meta-(tert-butyloxycarbonylamino)benzyl)-6-(α-cyclopropylmethyl-cyclopropylethyl)-4-hydroxy-2H-pyran-2-one (174485-01-9)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen / 5% platinum on charcoal / methanol / 5 h / 760.05 Torr

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 20 °C

3: sodium tetrahydroborate / tetrahydrofuran; ethanol / 3 h / 20 °C

4: toluene-4-sulfonic acid / benzene / Heating / reflux

With sodium tetrahydroborate; hydrogen; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; 5% platinum on charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; benzene;

Reference yield:

cyclopropyl-(3-aminophenyl)methanone (162174-75-6) → 3-(α-cyclopropyl-meta-(tert-butyloxycarbonylamino)benzyl)-6-(α-cyclopropylmethyl-cyclopropylethyl)-4-hydroxy-2H-pyran-2-one (174485-01-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 0 - 20 °C

2: sodium tetrahydroborate / tetrahydrofuran; ethanol / 3 h / 20 °C

3: toluene-4-sulfonic acid / benzene / Heating / reflux

With sodium tetrahydroborate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; benzene;

upstream raw materials:

cyclopropyl phenyl ketone

cyclopropyl-(3-nitrophenyl)methanone

cyclopropyl-(3-aminophenyl)methanone

benzyl chloroformate

Downstream raw materials:

3-(α-cyclopropyl-meta-aminobenzyl)-6-(α-cyclopropylmethyl-cyclopropylethyl)-4-hydroxy-2H-pyran-2-one