Bpiq-i

Base Information

Chemical Name:Bpiq-i
CAS No.:174709-30-9
Molecular Formula:C₁₆H₁₂BrN₅
Molecular Weight:354.209
Hs Code.:
DSSTox Substance ID:DTXSID60274366
Nikkaji Number:J720.939H
Wikidata:Q27075461
Pharos Ligand ID:M59LUZXTUGAZ
ChEMBL ID:CHEMBL174426
Mol file:174709-30-9.mol

Synonyms:8-((3-bromophenyl)amino)-3-methyl-3H-imidazo(4,5-g)quinazoline;BPIQ-I

Suppliers and Price of Bpiq-i

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
BPIQ-I ≥95%
1mg
$ 135.00

Cayman Chemical
BPIQ-I ≥95%
500μg
$ 75.00

Cayman Chemical
BPIQ-I ≥95%
5mg
$ 525.00

AK Scientific
Bpiq-i
5mg
$ 808.00

AK Scientific
Bpiq-i
1mg
$ 282.00

Total 3 raw suppliers

Chemical Property of Bpiq-i

Chemical Property:

PSA：55.63000
LogP:4.09560
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:353.02761
Heavy Atom Count:22
Complexity:395

Purity/Quality:

97% ^*data from raw suppliers

BPIQ-I ≥95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C=NC2=C1C=C3C(=C2)C(=NC=N3)NC4=CC(=CC=C4)Br
Description BPIQ-I is a quinazoline that inhibits the tyrosine kinase activity of the epidermal growth factor receptor (IC50 = 0.025 nM). It can inhibit the growth of SKOV3 and MDA-468 tumor cell lines with EC50 values of 6.5 and 30 μM, respectively.

Technology Process of Bpiq-i

There total 4 articles about Bpiq-i which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 591-19-5
m-Bromoaniline

: 174709-21-8
3-methyl-8-(methylthio)-3H-imidazo<4,5-g>quinazoline

: 174709-30-9
BPIQ-1

Guidance literature:: With m-bromoaniline hydrochloride; In isopropyl alcohol; for 1h; Heating;
DOI:10.1021/jm950692f

Reference yield:

: 105664-87-7
3-methyl-3H-imidazo<4,5-g>quinazoline-8(7H)-one

: 174709-30-9
BPIQ-1

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / P₂S₅, pyridine / 16 h / Heating

2: 82 percent / KOH / methanol; H₂O / 16 h / 20 °C

3: 52 percent / 3-bromoaniline hydrochloride / propan-2-ol / 1 h / Heating

With pyridine; potassium hydroxide; tetraphosphorus decasulfide; m-bromoaniline hydrochloride; In methanol; water; isopropyl alcohol;
DOI:10.1021/jm950692f

Reference yield:

: 174709-20-7
3-methyl-3H-imidazo<4,5-g>quinazoline-8(7H)-thione

: 174709-30-9
BPIQ-1

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / KOH / methanol; H₂O / 16 h / 20 °C

2: 52 percent / 3-bromoaniline hydrochloride / propan-2-ol / 1 h / Heating

With potassium hydroxide; m-bromoaniline hydrochloride; In methanol; water; isopropyl alcohol;
DOI:10.1021/jm950692f