2-Naphtylbenzyl ketone

Base Information

• Chemical Name: 2-Naphtylbenzyl ketone
• CAS No.: 1762-15-8
• Molecular Formula: C18H14O
• Molecular Weight: 246.309
• Hs Code.: 2914399090
• Mol file: 1762-15-8.mol

Synonyms:Ethanone, 1-(2-naphthalenyl)-2-phenyl-;

Chemical Property of 2-Naphtylbenzyl ketone

Chemical Property:

• PSA: 17.07000
• LogP: 4.26520

Purity/Quality:

95% ^*data from raw suppliers

1-(naphthalen-2-yl)-2-phenylethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Naphtylbenzyl ketone

There total 47 articles about 2-Naphtylbenzyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(naphthalen-2-yl)-2-phenylethan-1-ol (220063-61-6) → 1-(naphthalen-2-yl)-2-phenylethanone (1762-15-8)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 3h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c04316

Reference yield: 92.0%

iodobenzene (591-50-4) + methyl 2-naphthyl ketone (93-08-3) → 1-(naphthalen-2-yl)-2-phenylethanone (1762-15-8)

Guidance literature:

With potassium tert-butylate; iron(II) chloride; In dimethyl sulfoxide; for 0.333333h; Ambient temperature;

Reference yield: 89.0%

naphthalene-2-boronic acid (32316-92-0) + phenylacetonitrile (140-29-4) → 1-(naphthalen-2-yl)-2-phenylethanone (1762-15-8)

Guidance literature:

[Pd(μ-OH)(2,2'-bipyridine)]2(OSO2CF3)2; In nitromethane; for 24h; Heating;

DOI:10.1021/ol062438v

upstream raw materials:

sodium phenylacetate

naphthalene

phenylacetyl chloride

isopropylmagnesium chloride

Downstream raw materials:

Phenyl-β-naphthylessigsaeure-tosylamid

1-(naphthalen-2-yl)-2-phenylethane-1,2-dione

naphthalene-2-carboxylate

2-bromo-1-(naphthalen-2-yl)-2-phenylethan-1-one

Refernces

• 1、 Gu, Yuanyun,Zhang, Zhen,Wang, Yan-En,Dai, Ziteng,Yuan, Yaqi,Xiong, Dan,Li, Jie,Walsh, Patrick J.,Mao, Jianyou. "Benzylic Aroylation of Toluenes Mediated by a LiN(SiMe3)2/Cs+System". supporting information. p. 406 - 418. Retrieved 2022/01/14.
• 2、 Templ, Johanna,Schnürch, Michael. "Selective α-Methylation of Aryl Ketones Using Quaternary Ammonium Salts as Solid Methylating Agents". supporting information. p. 4305 - 4315. Retrieved 2022/03/16.