Ethyl 3-methoxy-2-naphthoate

Base Information

• Chemical Name: Ethyl 3-methoxy-2-naphthoate
• CAS No.: 7147-28-6
• Molecular Formula: C14H14 O3
• Molecular Weight: 230.263
• NSC Number: 28478
• DSSTox Substance ID: DTXSID70282856
• Wikidata: Q82017232
• Mol file: 7147-28-6.mol

Synonyms:7147-28-6;ethyl 3-methoxy-2-naphthoate;NSC28478;SCHEMBL1127591;DTXSID70282856;NSC-28478;3-Methoxy-naphthalene-2-carboxylic acid ethyl ester

Chemical Property of Ethyl 3-methoxy-2-naphthoate

Chemical Property:

• Vapor Pressure: 1.93E-05mmHg at 25°C
• Boiling Point: 362.4°C at 760 mmHg
• Flash Point: 151.4°C
• Density: 1.14g/cm³
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 230.094294304
• Heavy Atom Count: 17
• Complexity: 264

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CC2=CC=CC=C2C=C1OC

Technology Process of Ethyl 3-methoxy-2-naphthoate

There total 2 articles about Ethyl 3-methoxy-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

C15H18O4 (1529808-79-4) → 3-methoxy-[2]naphthoic acid ethyl ester (7147-28-6) + 1-methoxy-[2]naphthoic acid ethyl ester

Guidance literature:

With triethylamine; In toluene; for 4h; Reflux;

DOI:10.1002/chem.201301608

Reference yield:

ethanol (64-17-5) + 3-methoxy-2-naphthoic acid (883-62-5) → 3-methoxy-[2]naphthoic acid ethyl ester (7147-28-6)

Guidance literature:

With hydrogenchloride;

DOI:10.1080/09669580108667406

Reference yield:

3-methoxy-[2]naphthoic acid ethyl ester (7147-28-6) → 3-Amino-2-naphthol (5417-63-0)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate

2: hydrogen chloride; ethanol / anschliessendes Erwaermen

3: aqueous hydrochloric acid / 120 °C

With hydrogenchloride; ethanol; hydrazine hydrate;

DOI:10.1080/09669580108667406

upstream raw materials:

ethanol

3-methoxy-2-naphthoic acid

C₁₅H₁₈O₄

Downstream raw materials:

3-methoxy-2-naphthoic hydrazide

2-amino-3-methoxynaphthalene

N,N'-bis-(3-methoxy-[2]naphthoyl)-hydrazine

3-Amino-2-naphthol

Refernces