4-Ethylthiazole

Base Information

• Chemical Name: 4-Ethylthiazole
• CAS No.: 17626-72-1
• Molecular Formula: C5H7NS
• Molecular Weight: 113.183
• Hs Code.: 2934100090
• Mol file: 17626-72-1.mol

Synonyms:Thiazole,4-ethyl;4-Aethyl-thiazol;4-Ethylthiazole;2-Aethyl-thiazol;4-Ethylthiazol;

Chemical Property of 4-Ethylthiazole

Chemical Property:

• Vapor Pressure: 2.77mmHg at 25°C
• Boiling Point: 162.9oC at 760 mmHg
• PKA: 3.08±0.10(Predicted)
• Flash Point: 56.3oC
• PSA: 41.13000
• Density: 1.078g/cm3
• LogP: 1.70550

Purity/Quality:

99% ^*data from raw suppliers

4-Ethyl-1,3-thiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Ethylthiazole

There total 4 articles about 4-Ethylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

4-ethylthiazole-2-carboxylic acid ethyl ester (79247-88-4) → 4-ethylthiazole (17626-72-1) + 4-ethyl-1,3-thiazole-2-carboxylic acid (1181456-13-2)

Guidance literature:

With water; potassium hydroxide; for 1.25h; Reflux;

Reference yield:

N-methylimine of methyl ethyl ketone (3332-09-0) → 4,5-Dimethylthiazole (3581-91-7) + 4-ethylthiazole (17626-72-1)

Guidance literature:

With sulfur dioxide; soda-lime; zirconium(IV) oxide; at 450 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

Reference yield:

formamide (77287-34-4,77287-35-5,60100-09-6) + 1-Bromo-2-butanone (816-40-0) → 4-ethylthiazole (17626-72-1)

Guidance literature:

With tetraphosphorus decasulfide;

upstream raw materials:

formamide

1-Bromo-2-butanone

N-methylimine of methyl ethyl ketone

4-ethylthiazole-2-carboxylic acid ethyl ester

Downstream raw materials:

1-(4-ethyl-thiazol-2-yl)-ethanone

Refernces

• 1、 Amato, Joseph S.,Karady, Sandor,Phillips, Brian T.,Weinstock, Leonard M.. "A NEW VAPOR-PHASE SYNTHESIS OF THIAZOLES". . p. 1947 - 1949. Retrieved 2007/10/02.