2H-1,4-Benzoxazine-3-carboxylic acid, 3,4-dihydro-, ethyl ester

Base Information

Chemical Name:2H-1,4-Benzoxazine-3-carboxylic acid, 3,4-dihydro-, ethyl ester
CAS No.:177202-60-7
Molecular Formula:C11H13NO3
Molecular Weight:207.229
Hs Code.:

Synonyms:ethyl 3,4-dihydro-2H-benzo[b][1,4]oxazine-3-carboxylate;3(R,S)ethoxycarbonyl-3,4-dihydro-2H-1,4-benzooxazine;

Suppliers and Price of 2H-1,4-Benzoxazine-3-carboxylic acid, 3,4-dihydro-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl3,4-dihydro-2H-benzo[b][1,4]oxazine-3-carboxylate 95+%
1g
$ 412.00

Chemenu
Ethyl3,4-dihydro-2H-benzo[b][1,4]oxazine-3-carboxylate 95%
1g
$ 389.00

Alichem
Ethyl3,4-dihydro-2h-benzo[b][1,4]oxazine-3-carboxylate
1g
$ 442.38

Alichem
Ethyl3,4-dihydro-2h-benzo[b][1,4]oxazine-3-carboxylate
250mg
$ 176.75

Total 1 raw suppliers

Chemical Property of 2H-1,4-Benzoxazine-3-carboxylic acid, 3,4-dihydro-, ethyl ester

Chemical Property:

PSA：47.56000
LogP:1.56060

Purity/Quality:: Ethyl3,4-dihydro-2H-benzo[b][1,4]oxazine-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2H-1,4-Benzoxazine-3-carboxylic acid, 3,4-dihydro-, ethyl ester

There total 1 articles about 2H-1,4-Benzoxazine-3-carboxylic acid, 3,4-dihydro-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 95-55-6
2-amino-phenol

: 3674-13-3
2,3-dibromopropionic acid ethyl ester

: 177202-60-7
ethyl 3,4-dihydro-2H-benzo [b][1,4]oxazine-3-carboxylate

: 22244-22-0
ethyl 3,4-dihydro-2H-benzo [b][1,4]oxazine-2-carboxylate

Guidance literature:: With potassium carbonate; In acetone; for 18h; Heating;
DOI:10.1002/jhet.5570380133

Reference yield: 80.0%

: 16271-33-3
2,4-Dichlorobenzenesulfonyl chloride

: 177202-60-7
ethyl 3,4-dihydro-2H-benzo [b][1,4]oxazine-3-carboxylate

: 1191240-20-6
C₁₈H₁₇Cl₂NO₅S

Guidance literature:: With pyridine; at 20 ℃;

Reference yield:

: 177202-60-7
ethyl 3,4-dihydro-2H-benzo [b][1,4]oxazine-3-carboxylate

: 1401076-01-4
(1R)-N-((4-(4-methoxyphenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)methyl)-1-(naphthalen-1-yl)ethanamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: trimethylaluminum / toluene / 0.25 h / 50 °C / Inert atmosphere

1.2: 5 h / 110 °C

2.1: ethyl acetate; hexane / Resolution of diastereomers

3.1: dimethylsulfide borane complex / tetrahydrofuran / 5 h / 60 - 70 °C

3.2: 0.67 h / 0 - 65 °C

3.3: 0 °C / pH 10

4.1: caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / toluene / 20 h / 110 °C / Inert atmosphere

With dimethylsulfide borane complex; trimethylaluminum; caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In tetrahydrofuran; hexane; ethyl acetate; toluene;