5-Chloro-2-methyl-1,8-naphthyridine

Base Information

Chemical Name:5-Chloro-2-methyl-1,8-naphthyridine
CAS No.:1772-45-8
Molecular Formula:C9H7ClN2
Molecular Weight:178.61800
Hs Code.:2933990090
European Community (EC) Number:827-982-0
DSSTox Substance ID:DTXSID30483145
Nikkaji Number:J1.681.953K
Wikidata:Q82320205
Mol file:1772-45-8.mol

Synonyms:5-Chloro-2-methyl-1,8-naphthyridine;1772-45-8;1,8-Naphthyridine, 5-chloro-2-methyl-;2-methyl-5-chloro-1,8-naphthyridine;SCHEMBL2016453;DTXSID30483145;GLDRQEIMGVCUET-UHFFFAOYSA-N;BAA77245;AKOS000320478;AT22589;5-chloro-2-methyl-[1,8]naphthyridine;CS-0448498;EN300-133594;A924834;F2124-0996;Z1198180961

Suppliers and Price of 5-Chloro-2-methyl-1,8-naphthyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-chloro-2-methyl-1,8-naphthyridine
100mg
$ 350.00

TRC
5-chloro-2-methyl-1,8-naphthyridine
50mg
$ 240.00

TRC
5-chloro-2-methyl-1,8-naphthyridine
10mg
$ 65.00

Crysdot
5-Chloro-2-methyl-1,8-naphthyridine 95+%
1g
$ 693.00

Crysdot
5-Chloro-2-methyl-1,8-naphthyridine 95+%
10g
$ 1771.00

Crysdot
5-Chloro-2-methyl-1,8-naphthyridine 95+%
5g
$ 1325.00

AK Scientific
5-Chloro-2-methyl-1,8-naphthyridine
250mg
$ 738.00

Total 6 raw suppliers

Chemical Property of 5-Chloro-2-methyl-1,8-naphthyridine

Chemical Property:

PSA：25.78000
LogP:2.59160
XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:178.0297759
Heavy Atom Count:12
Complexity:163

Purity/Quality:

97% ^*data from raw suppliers

5-chloro-2-methyl-1,8-naphthyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC2=NC=CC(=C2C=C1)Cl

Technology Process of 5-Chloro-2-methyl-1,8-naphthyridine

There total 12 articles about 5-Chloro-2-methyl-1,8-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1569-18-2
7-methyl-1,8-naphthyridin-4-ol

: 1772-45-8
5-chloro-2-methyl-1,8-naphthyridine

Guidance literature:: 2-methyl-5-hydroxy-1,8-naphthyridine; With trichlorophosphate; at 50 ℃; for 6h;

With ammonia; In water; pH=10;

Reference yield: 76.0%

: 49655-73-4
7-methyl[1,8]naphthyridin-4(1H)-one

: 1772-45-8
5-chloro-2-methyl-1,8-naphthyridine

Guidance literature:: With trichlorophosphate; In toluene; at 100 ℃;
DOI:10.1016/S0960-894X(02)00026-4

Reference yield:

: 35482-56-5
ethyl 7-methyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

: 1772-45-8
5-chloro-2-methyl-1,8-naphthyridine

Guidance literature:: Multi-step reaction with 6 steps

1: KOH / ethanol

2: K₂CO₃ / dimethylformamide

3: NaOH / ethanol

4: 78 percent / KCN / dimethylsulfoxide / 100 °C

5: 76 percent / HCOONH₄ / Pd(OH)2 / methanol

6: 76 percent / POCl₃ / toluene / 100 °C

With potassium cyanide; potassium hydroxide; sodium hydroxide; ammonium formate; potassium carbonate; trichlorophosphate; palladium dihydroxide; In methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0960-894X(02)00026-4