1H-Imidazole, 2-(3-chloro-4-methylphenyl)-1-[4-(methylsulfonyl)phenyl]-4-(trifluorometh yl)-

Base Information

Chemical Name:1H-Imidazole, 2-(3-chloro-4-methylphenyl)-1-[4-(methylsulfonyl)phenyl]-4-(trifluorometh yl)-
CAS No.:177660-65-0
Molecular Formula:C18H14ClF3N2O2S
Molecular Weight:414.836
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Imidazole, 2-(3-chloro-4-methylphenyl)-1-[4-(methylsulfonyl)phenyl]-4-(trifluorometh yl)-

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 1H-Imidazole, 2-(3-chloro-4-methylphenyl)-1-[4-(methylsulfonyl)phenyl]-4-(trifluorometh yl)-

There total 4 articles about 1H-Imidazole, 2-(3-chloro-4-methylphenyl)-1-[4-(methylsulfonyl)phenyl]-4-(trifluorometh yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 177662-28-1
2-(3-chloro-4-methylphenyl)-4-hydroxy-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-4,5-dihydro-1H-imidazole

: 177660-65-0
2-(3-chloro-4-methylphenyl)-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-1H-imidazole

Guidance literature:: With p-toluenesulfonic acid monohydrate; In dichloromethane; ethyl acetate; toluene;

Reference yield:

: 21423-81-4
3-chloro-4-methylbenzonitrile

: 177660-65-0
2-(3-chloro-4-methylphenyl)-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: trimethylaluminum / 1.) toluene, a) 0 deg C - RT, b) RT, 3.5 h, 2.) toluene, 70 deg C - 75 deg C, 17 h

2: sodium hydrogencarbonate / isopropyl alcohol / 20 h / 75 - 80 °C

3: toluene-4-sulfonic acid / toluene / 72 h / Heating

With trimethylaluminum; sodium hydrogencarbonate; toluene-4-sulfonic acid; In isopropyl alcohol; toluene;
DOI:10.1021/jm9700225

Reference yield:

: 5470-49-5
4-methanesulfonylphenylamine

: 177660-65-0
2-(3-chloro-4-methylphenyl)-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: trimethylaluminum / 1.) toluene, a) 0 deg C - RT, b) RT, 3.5 h, 2.) toluene, 70 deg C - 75 deg C, 17 h

2: sodium hydrogencarbonate / isopropyl alcohol / 20 h / 75 - 80 °C

3: toluene-4-sulfonic acid / toluene / 72 h / Heating

With trimethylaluminum; sodium hydrogencarbonate; toluene-4-sulfonic acid; In isopropyl alcohol; toluene;
DOI:10.1021/jm9700225