Technology Process of 1H-1,4-Benzodiazepine-1-acetic acid,
3-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3-dihydro-2-oxo-5-phenyl-,
ethyl ester
There total 6 articles about 1H-1,4-Benzodiazepine-1-acetic acid,
3-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3-dihydro-2-oxo-5-phenyl-,
ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamic acid tert-butyl ester;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.5h;
ethyl bromoacetate;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 4h;
DOI:10.1021/jm049248f
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Pd(OAc)2; TEA; triethylsilane / CH2Cl2 / 3 h / 20 °C
2.1: 3.78 g / CH2Cl2 / 2 h / 20 °C
3.1: NaH / dimethylformamide / 0.5 h / 0 °C
3.2: 88 percent / dimethylformamide / 4 h / 20 °C
With
triethylsilane; palladium diacetate; TEA; sodium hydride;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049248f
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 7.0 g / NH4OAc; AcOH / 12 h / 20 °C
2.1: Pd(OAc)2; TEA; triethylsilane / CH2Cl2 / 3 h / 20 °C
3.1: 3.78 g / CH2Cl2 / 2 h / 20 °C
4.1: NaH / dimethylformamide / 0.5 h / 0 °C
4.2: 88 percent / dimethylformamide / 4 h / 20 °C
With
triethylsilane; palladium diacetate; TEA; ammonium acetate; sodium hydride; acetic acid;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm049248f