(-)-N-Formyl-L-valine [(S)-2-formylamino-3-methylbutyl] ester

Base Information

• Chemical Name: (-)-N-Formyl-L-valine [(S)-2-formylamino-3-methylbutyl] ester
• CAS No.: 94899-85-1
• Molecular Formula: C12H22 N2 O4
• Molecular Weight: 258.318
• Mol file: 94899-85-1.mol

Synonyms:L-Valine,N-formyl-, 2-(formylamino)-3-methylbutyl ester, (S)-; Valinotricin

Chemical Property of (-)-N-Formyl-L-valine [(S)-2-formylamino-3-methylbutyl] ester

Chemical Property:

• Melting Point: 128 - 129 °C (hexane)
• PSA: 84.50000
• LogP: 2.12440

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-N-Formyl-L-valine [(S)-2-formylamino-3-methylbutyl] ester

There total 6 articles about (-)-N-Formyl-L-valine [(S)-2-formylamino-3-methylbutyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

formic acid (64-18-6) + 2-Amino-3-methyl-butyric acid 2-formylamino-3-methyl-butyl ester (94899-75-9) → valinotricin (94899-85-1)

Guidance literature:

With acetic anhydride; 0 deg C, 30 min, r.t., 6 h;

DOI:10.1248/cpb.32.4419

Reference yield: 9.0%

N-formyl-L-valine (4289-97-8) + (S)-N-[1-(hydroxymethyl)-2-methylpropyl]formamide (89876-66-4) → valinotricin (94899-85-1)

Guidance literature:

With 4-aminopyridine; dicyclohexyl-carbodiimide; In dichloromethane; for 22h; Ambient temperature;

DOI:10.1248/cpb.32.4419

Reference yield:

(S)-valinol (2026-48-4,473-75-6) → valinotricin (94899-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Ac₂O; 2.) 0.2N NaOH, EtOH / 1.) 0 deg C, 30 min, r.t., 5 h; 2.) reflux, 2 h

2: 9 percent / dicyclohexylcarbodiimide, 4-aminopyridine / CH₂Cl₂ / 22 h / Ambient temperature

With 4-aminopyridine; sodium hydroxide; ethanol; acetic anhydride; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1248/cpb.32.4419

upstream raw materials:

formic acid

2-Amino-3-methyl-butyric acid 2-formylamino-3-methyl-butyl ester

N-formyl-L-valine

(S)-N-[1-(hydroxymethyl)-2-methylpropyl]formamide

Downstream raw materials:

N-formyl-L-valine

(S)-N-[1-(hydroxymethyl)-2-methylpropyl]formamide