1-Pyrrolidinecarboxylic acid, 2-[(1E)-2-carboxy-1-propenyl]-, 1-(1,1-dimethylethyl) ester, (2S)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[(1E)-2-carboxy-1-propenyl]-, 1-(1,1-dimethylethyl) ester, (2S)-
CAS No.:179040-16-5
Molecular Formula:C13H21NO4
Molecular Weight:255.314
Hs Code.:
Mol file:179040-16-5.mol

Synonyms:(S)-3-(1'-tert-butoxycarbonyl-2'-pyrrolidinyl)-2-methyl-prop-2-enoic acid;

Suppliers and Price of 1-Pyrrolidinecarboxylic acid, 2-[(1E)-2-carboxy-1-propenyl]-, 1-(1,1-dimethylethyl) ester, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[(1E)-2-carboxy-1-propenyl]-, 1-(1,1-dimethylethyl) ester, (2S)-

Chemical Property:

PSA：66.84000
LogP:2.35470

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[(1E)-2-carboxy-1-propenyl]-, 1-(1,1-dimethylethyl) ester, (2S)-

There total 2 articles about 1-Pyrrolidinecarboxylic acid, 2-[(1E)-2-carboxy-1-propenyl]-, 1-(1,1-dimethylethyl) ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.6%

: 133565-38-5
(2R,3R)-3-[(2S)-1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl]-3-hydroxy-2-methylpropanoic acid

: 120205-50-7
N-Boc-(2R,3R,4S)-dolaproine

: (R)-2-((1R,7aS)-3-Oxo-tetrahydro-pyrrolo[1,2-c]oxazol-1-yl)-propionic acid

: 179040-16-5
[L-(trans)]-N-(t-butoxycarbonyl)-2-[2'-carboxy-2'-methyl-1'-ethenyl]pyrrolidine

Guidance literature:: With sodium hydride; methyl iodide; In tetrahydrofuran; at 0 ℃; for 48h;
DOI:10.1055/s-1996-4296

Reference yield: 5.3%

: 133565-38-5
(2R,3R)-3-[(2S)-1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl]-3-hydroxy-2-methylpropanoic acid

: 74-88-4
methyl iodide

: 120205-50-7
N-Boc-(2R,3R,4S)-dolaproine

: (R)-2-((1R,7aS)-3-Oxo-tetrahydro-pyrrolo[1,2-c]oxazol-1-yl)-propionic acid

: 179040-16-5
[L-(trans)]-N-(t-butoxycarbonyl)-2-[2'-carboxy-2'-methyl-1'-ethenyl]pyrrolidine

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 ℃; for 48h;
DOI:10.1055/s-1996-4296

Reference yield:

: 179040-16-5
[L-(trans)]-N-(t-butoxycarbonyl)-2-[2'-carboxy-2'-methyl-1'-ethenyl]pyrrolidine

: (S)-4-Methyl-2-[(S)-2-((E)-2-methyl-3-(S)-pyrrolidin-2-yl-acryloylamino)-3-phenyl-propionylamino]-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: EDCI; 1-hydroxybenzotriazole

2: TFA / CH₂Cl₂

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jo034361j