4-(3-Fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate Ethyl

Base Information

Chemical Name:4-(3-Fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate Ethyl
CAS No.:179420-67-8
Molecular Formula:C14H17FO4
Molecular Weight:268.285
Hs Code.:
Mol file:179420-67-8.mol

Synonyms:ethyl 4-(5-fluoro-3-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate;4-(3-fluoro-5-hydroxy-phenyl)-tetrahydro-pyran-4-carboxylic acid methyl ester;4-(3-Fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate Ethyl;

Suppliers and Price of 4-(3-Fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate Ethyl

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

TRC
4-(3-Fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylateEthyl
250mg
$ 1320.00

Total 1 raw suppliers

Chemical Property of 4-(3-Fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate Ethyl

Chemical Property:

PSA：55.76000
LogP:2.14260

Purity/Quality:: 4-(3-Fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylateEthyl ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 4-(3-Fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate Ethyl is an intermediate used in the synthesis of an imidazole 5-lipoxygenase (5-LO) inhibitor.

Technology Process of 4-(3-Fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate Ethyl

There total 8 articles about 4-(3-Fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate Ethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 179420-66-7
ethyl 4-(5-benzyloxy-3-fluorophenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

: 179420-67-8
ethyl 4-(3-fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃;
DOI:10.1055/s-2004-831227

Reference yield:

: 130722-44-0
5-benzyloxy-3-fluorophenyl bromide

: 179420-67-8
ethyl 4-(3-fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 34 percent / NaH; CuBr / dioxane / Heating

2: 57 percent / aq. LiOH / dimethylsulfoxide / Heating

3: 58 percent / NaH; NaI; 15-crown-15 / dimethylformamide / 20 °C

4: 100 percent / H₂ / Pd/C / ethanol / 20 °C

With lithium hydroxide; 15-crown-15; hydrogen; sodium hydride; sodium iodide; copper(I) bromide; palladium on activated charcoal; In 1,4-dioxane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1055/s-2004-831227

Reference yield:

: 179420-65-6
ethyl 3-benzyloxy-5-fluorophenylacetate

: 179420-67-8
ethyl 4-(3-fluoro-5-hydroxyphenyl)-3,4,5,6-tetrahydro-2H-pyran-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / NaH; NaI; 15-crown-15 / dimethylformamide / 20 °C

2: 100 percent / H₂ / Pd/C / ethanol / 20 °C

With 15-crown-15; hydrogen; sodium hydride; sodium iodide; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1055/s-2004-831227