Benzoic acid, 2,4,6-trimethyl-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Benzoic acid, 2,4,6-trimethyl-, 1,1-dimethylethyl ester
• CAS No.: 1795-80-8
• Molecular Formula: C14H20O2
• Molecular Weight: 220.312
• Mol file: 1795-80-8.mol

Synonyms:

Chemical Property of Benzoic acid, 2,4,6-trimethyl-, 1,1-dimethylethyl ester

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzoic acid, 2,4,6-trimethyl-, 1,1-dimethylethyl ester

There total 12 articles about Benzoic acid, 2,4,6-trimethyl-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

S-2-pyridyl 2,4,6-trimethylbenzothioate (81787-27-1) + tert-butyl alcohol (75-65-0) → tert-butyl 2,4,6-trimethylbenzoate (1795-80-8)

Guidance literature:

With copper(ll) bromide; In acetonitrile; for 0.166667h; Ambient temperature; other metal salts, other solvents, other temperature, other times;

DOI:10.1021/jo00184a009

Reference yield: 94.0%

2-pyridyl mesitoate (63540-63-6) + tert-butyl alcohol (75-65-0) → tert-butyl 2,4,6-trimethylbenzoate (1795-80-8)

Guidance literature:

With copper(ll) bromide; In acetonitrile; for 8h; Ambient temperature; 80 deg C, 0.25 h;

DOI:10.1021/jo00184a009

Reference yield: 91.0%

mesitylenecarboxylic acid (480-63-7) + tert-butyl alcohol (75-65-0) → tert-butyl 2,4,6-trimethylbenzoate (1795-80-8)

Guidance literature:

With pyridine; at 115 ℃; for 0.5h;

DOI:10.1246/bcsj.56.639

upstream raw materials:

mesitylene-2-carboxylic acid chloride

tert-butyl alcohol

methyl 2,4,6-trimethylbenzoate

mesitylenecarboxylic acid

Downstream raw materials:

tert-butylbenzene

mesitylenecarboxylic acid

mesitylene-2-carboxylic acid chloride

(2,4,6-trimethylbenzoyl)diphenylphosphine oxide

Refernces

• 1、 La, Minh Thanh,Kim, Hee-Kwon. "A fast and practical synthesis of tert-butyl esters from 2-tert-butoxypyridine using boron trifluoride·diethyl etherate under mild conditions". . p. 3748 - 3754. Retrieved 2018/05/28.
• 2、 Zhao, Hong,Pendri, Annapurna,Greenwald, Richard B.. "General procedure for acylation of 3° alcohols: Scandium triflate/DMAP reagent". . p. 7559 - 7562. Retrieved 2007/10/03.