2,2-Dimethyl-1,2,3,4-tetrahydroquinolin-7-amine

Base Information

• Chemical Name: 2,2-Dimethyl-1,2,3,4-tetrahydroquinolin-7-amine
• CAS No.: 179899-22-0
• Molecular Formula: C11H16N2
• Molecular Weight: 176.25800
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID40441352
• Wikidata: Q82258108
• Mol file: 179899-22-0.mol

Synonyms:179899-22-0;2,2-Dimethyl-1,2,3,4-tetrahydroquinolin-7-amine;7-amino-1,2,3,4-tetrahydro-2,2-dimethylquinoline;2,2-dimethyl-3,4-dihydro-1H-quinolin-7-amine;7-Quinolinamine, 1,2,3,4-tetrahydro-2,2-dimethyl-;2,2-DIMETHYL-1,2,3,4-TETRAHYDRO-QUINOLIN-7-YLAMINE;SCHEMBL6649459;DTXSID40441352;LNNIPFBSWGVRIX-UHFFFAOYSA-N;AKOS022173345;EN300-7355325;A849427;7-Amino-2,2-Dimethyl-1,2,3,4-Tetrahydroquinoline

Chemical Property of 2,2-Dimethyl-1,2,3,4-tetrahydroquinolin-7-amine

Chemical Property:

• PSA: 38.05000
• LogP: 3.12470
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 176.131348519
• Heavy Atom Count: 13
• Complexity: 189

Purity/Quality:

97% ^*data from raw suppliers

2,2-Dimethyl-1,2,3,4-tetrahydroquinolin-7-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CCC2=C(N1)C=C(C=C2)N)C

Technology Process of 2,2-Dimethyl-1,2,3,4-tetrahydroquinolin-7-amine

There total 12 articles about 2,2-Dimethyl-1,2,3,4-tetrahydroquinolin-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

C11H14N2O2 → 7-amino-1,2,3,4-tetrahydro-2,2-dimethylquinoline (179899-22-0)

Guidance literature:

C₁₁H₁₄N₂O₂; With tris(pentafluorophenyl)borate; In dichloromethane; at 20 ℃; for 0.166667h; Inert atmosphere;

With n-butylsilane; In dichloromethane; for 12h; Inert atmosphere;

Reference yield:

1,2,3,4-tetrahydro-2,2-dimethyl-7-nitroquinoline (201541-36-8) → 7-amino-1,2,3,4-tetrahydro-2,2-dimethylquinoline (179899-22-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; for 6h;

DOI:10.1021/jm970699s

Reference yield:

2,2-dimethyl-1,2,3,4-tetrahydroquinoline (20364-30-1) → 7-amino-1,2,3,4-tetrahydro-2,2-dimethylquinoline (179899-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄, HNO₃ / 10 h / -10 °C

2: H₂ / Pd/C / ethyl acetate / 15 h / Ambient temperature

With sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In ethyl acetate;

upstream raw materials:

1,2,3,4-tetrahydro-2,2-dimethyl-7-nitroquinoline

2,2-dimethyl-1,2,3,4-tetrahydroquinoline

1,2,3,4-tetrahydro-2,2-dimethylquinolin-4-one

1-tert-butoxycarbonyl-1,2,3,4-tetrahydro-2,2-dimethyl-4-quinolinone