1,2,3,4-tetrahydro-2,2-diMethyl-7-nitroquinoline

Base Information

• Chemical Name: 1,2,3,4-tetrahydro-2,2-diMethyl-7-nitroquinoline
• CAS No.: 201541-36-8
• Molecular Formula: C11H14N2O2
• Molecular Weight: 206.24106
• Mol file: 201541-36-8.mol

Synonyms:1,2,3,4-tetrahydro-2,2-diMethyl-7-nitroquinoline

Chemical Property of 1,2,3,4-tetrahydro-2,2-diMethyl-7-nitroquinoline

Chemical Property:

• PSA: 57.85000
• LogP: 3.39270

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2,3,4-tetrahydro-2,2-diMethyl-7-nitroquinoline

There total 6 articles about 1,2,3,4-tetrahydro-2,2-diMethyl-7-nitroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2,2-dimethyl-1,2,3,4-tetrahydroquinoline (20364-30-1) → 1,2,3,4-tetrahydro-2,2-dimethyl-7-nitroquinoline (201541-36-8)

Guidance literature:

With sulfuric acid; nitric acid; at -5 ℃; for 0.25h;

DOI:10.1021/jm970699s

Reference yield:

2,2-dimethyl-1,2-dihydroquinoline (14465-61-3) → 1,2,3,4-tetrahydro-2,2-dimethyl-7-nitroquinoline (201541-36-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / H₂ / 10percent Pd/C / ethanol; ethyl acetate / 4 h

2: 57 percent / HNO₃, H₂SO₄ / 0.25 h / -5 °C

With sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In ethanol; ethyl acetate;

DOI:10.1021/jm970699s

Reference yield:

3-methyl-3-phenylamino-1-butyne (7471-09-2) → 1,2,3,4-tetrahydro-2,2-dimethyl-7-nitroquinoline (201541-36-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / CuCl / tetrahydrofuran / 14 h / Heating

2: 99 percent / H₂ / 10percent Pd/C / ethanol; ethyl acetate / 4 h

3: 57 percent / HNO₃, H₂SO₄ / 0.25 h / -5 °C

With sulfuric acid; hydrogen; nitric acid; copper(l) chloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate;

DOI:10.1021/jm970699s

upstream raw materials:

2,2-dimethyl-1,2,3,4-tetrahydroquinoline

1,2,3,4-tetrahydro-2,2-dimethylquinolin-4-one

1-tert-butoxycarbonyl-1,2,3,4-tetrahydro-2,2-dimethyl-4-quinolinone

2,2-dimethyl-1,2-dihydroquinoline

Downstream raw materials:

7-amino-1,2,3,4-tetrahydro-2,2-dimethylquinoline

Refernces

• 1、 Zhi, Lin,Tegley, Christopher M.,Marschke, Keith B.,Jones, Todd K.. "Switching Androgen Receptor Antagonists to Agonists by Modifying C-Ring Substituents on Piperidinoquinolinone". . p. 1008 - 1012. Retrieved 2007/10/03.