20364-30-1

Basic information

• Product Name: 4-METHYLPYRIDINE-N-OXIDE
• Synonyms: 1,2,3,4-Tetrahydro-2,2-dimethylquinoline
• CAS NO: 20364-30-1
• Molecular Formula: C₁₁H₁₅N
• Molecular Weight: 161.24
• Mol File: 20364-30-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 95-98 °C(Press: 2 Torr)
• Appearance: /
• Density: 0.944±0.06 g/cm3(Predicted)
• PKA: 5.22±0.40(Predicted)
• CAS DataBase Reference: 4-METHYLPYRIDINE-N-OXIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYLPYRIDINE-N-OXIDE(20364-30-1)
• EPA Substance Registry System: 4-METHYLPYRIDINE-N-OXIDE(20364-30-1)

Safety Data

• Hazardous Substances Data: 20364-30-1(Hazardous Substances Data)

Usage

General Description

4-Methylpyridine-N-oxide, also known as 4-picoline N-oxide, is a chemical compound with the molecular formula C6H7NO. It is a derivative of pyridine and is a colorless to pale yellow liquid at room temperature. 4-Methylpyridine-N-oxide is used as a reagent in organic synthesis, and as a solvent in chemical reactions. It is also used as a precursor in the production of pharmaceuticals, pesticides, and other organic compounds. The compound is known to have a strong odor and can cause irritation to the eyes, skin, and respiratory system upon exposure, making it important to handle with care.

Upstream product

• 139058-37-0 3-iodo-2,2-dimethyl-1,2,3,4-tetrahydroquinoline 
• 62-53-3 aniline 
• 78-79-5 isoprene 
• 861216-48-0 tert-butyl 2-methylbut-3-en-2-yl carbonate 
• 60173-64-0 N-(1,1-dimethylprop-2-en-1-yl)aniline 
• 27125-61-7 2-(3-methylbut-2-en-1-yl)aniline 
• 104177-71-1 o-isopentylaniline 
• 1111-97-3 3-chloro-3-methylbut-1-yne 
• 870-63-3 prenyl bromide 
• 130074-91-8 2,2,2-trifluoro-N-<2-(3-methylbut-2-enyl)phenyl>acetamide 
• 2727-71-1 N-(2-bromophenyl)-2,2,2-trifluoroacetamide 
• 7471-09-2 3-methyl-3-phenylamino-1-butyne 
• 179898-87-4 1-tert-butoxycarbonyl-1,2,3,4-tetrahydro-2,2-dimethyl-4-quinolinone 
• 7553-56-2 iodine 

Downstream Products

• 179899-22-0 7-amino-1,2,3,4-tetrahydro-2,2-dimethylquinoline 
• 201541-36-8 1,2,3,4-tetrahydro-2,2-dimethyl-7-nitroquinoline 
• 88774-00-9 N-(2-trifluoromethylbenzoyl)-2,2-dimethyl-1,2,3,4-tetrahydroquinoline 

Relevant articles and documents

SUBSTITUTED, SATURATED AND UNSATURATED N-HETEROCYCLIC CARBOXAMIDES AND RELATED COMPOUNDS FOR THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted, saturated and unsaturated N-heterocyclic carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.

AGENTS AND METHODS FOR THE TREATMENT OF PROLIFERATIVE DISEASES

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Synthesis and biological activity of a novel series of nonsteroidal, peripherally selective androgen receptor antagonists derived from 1,2- dihydropyridono[5,6-g]quinolines

A new nonsteroidal antiandrogenic pharmacophore has been discovered using cell-based cotransfection assays with human androgen receptor (hAR). This series of AR antagonists is structurally characterized by a linear tricyclic 1,2-dihydropyridono[5,6-g]quinoline core. Analogues inhibit AR- mediated reporter gene expression and bind to AR as potently as or better than any known AR antagonists. Several analogues also showed excellent in vivo activity in classic rodent models of AR antagonism, inhibiting growth of rat ventral prostate and seminal vesicles, without accompanying increases in serum gonadotropin and testosterone levels, as is seen with other AR antagonists. Investigations of structure - activity relationships surrounding this pharmacophore resulted in molecules with complete specificity for AR, antagonist activity on an AR mutant commonly observed in prostate cancer patients, and improved in vivo efficacy. Molecules based on this series of compounds have the potential to provide unique and effective clinical opportunities for treatment of prostate cancer and other androgen-dependent diseases.