Carbamic acid, [(trans-4-formylcyclohexyl)methyl]-, 1,1-dimethylethyl ester

Base Information

• Chemical Name: Carbamic acid, [(trans-4-formylcyclohexyl)methyl]-, 1,1-dimethylethyl ester
• CAS No.: 180046-90-6
• Molecular Formula: C13H23NO3
• Molecular Weight: 241.331
• Mol file: 180046-90-6.mol

Synonyms:(tert-butoxy)-N-[(trans-4-formylcyclohexyl)methyl]carboxamide;tert-butyl ((trans-4-formylcyclohexyl)methyl)carbamate;Boc-Tra-H;trans-4-N-t-butoxycarbonylaminomethylcyclohexylaldehyde;trans-4-(N-tert-Butoxycarbonylaminomethyl)cyclohexanecarboxaldehyde;

Chemical Property of Carbamic acid, [(trans-4-formylcyclohexyl)methyl]-, 1,1-dimethylethyl ester

Chemical Property:

• Boiling Point: 355.5±15.0 °C(Predicted)
• PSA: 55.40000
• Density: 1.053±0.06 g/cm3(Predicted)
• LogP: 2.90730

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl((trans-4-formylcyclohexyl)methyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Carbamic acid, [(trans-4-formylcyclohexyl)methyl]-, 1,1-dimethylethyl ester

There total 9 articles about Carbamic acid, [(trans-4-formylcyclohexyl)methyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Boc-Tra-N(OCH3)CH3 (248953-91-5) → trans 4-(tert-butyloxycarbonylaminoethyl)cyclohexaneacetaldehyde (180046-90-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.25h;

Reference yield: 79.0%

tert-butyl (((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl)carbamate (172348-63-9) → trans 4-(tert-butyloxycarbonylaminoethyl)cyclohexaneacetaldehyde (180046-90-6)

Guidance literature:

tert-butyl (((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl)carbamate; With triethylamine; In dichloromethane;

With pyridine-SO₃ complex; In dichloromethane; dimethyl sulfoxide; at 0 ℃; for 2h;

DOI:10.1021/acsmedchemlett.7b00406

Reference yield: 76.0%

trans-(4-Hydroxymethyl-cyclohexylmethyl)-carbamic acid tert-butyl ester (1018674-46-8) → trans 4-(tert-butyloxycarbonylaminoethyl)cyclohexaneacetaldehyde (180046-90-6)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane;

upstream raw materials:

Boc-Tra-N(OCH₃)CH₃

tert-butyl (((1r,4r)-4-(hydroxymethyl)cyclohexyl)methyl)carbamate

di-tert-butyl dicarbonate

trans-4-aminomethyl-cyclohexyl-carboxylic acid

Downstream raw materials:

Boc-Tra-ψ(CH2-NH)-Phe-APAA-OBzl

trans-((4-aminomethyl)cyclohexylmethyl)carbamic acid tert-butyl ester