ethyl 1-[(phenylcarbamoyl)amino]cyclohexanecarboxylate

Base Information

• Chemical Name: ethyl 1-[(phenylcarbamoyl)amino]cyclohexanecarboxylate
• CAS No.: 4896-09-7
• Molecular Formula: C16H22 N2 O3
• Molecular Weight: 290.3575
• Mol file: 4896-09-7.mol

Synonyms:Cyclohexanecarboxylicacid, 1-(3-phenylureido)-, ethyl ester (7CI,8CI)

Chemical Property of ethyl 1-[(phenylcarbamoyl)amino]cyclohexanecarboxylate

Chemical Property:

• Vapor Pressure: 1.46E-06mmHg at 25°C
• Boiling Point: 398.6°C at 760 mmHg
• Flash Point: 194.9°C
• Density: 1.15g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 1-[(phenylcarbamoyl)amino]cyclohexanecarboxylate

There total 3 articles about ethyl 1-[(phenylcarbamoyl)amino]cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-aminocyclohexane carboxylic acid (2756-85-6) → 1-(3-Phenyl-ureido)-cyclohexanecarboxylic acid ethyl ester (4896-09-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen chloride gas / Heating

2: CHCl₃ / 3 h / 0 - 20 °C

With hydrogenchloride; In chloroform;

DOI:10.3797/scipharm.aut-01-204

Reference yield:

1-amino-cyclohexanecarboxylic acid ethyl ester hydrochloride (63203-48-5) + phenyl isocyanate (103-71-9) → 1-(3-Phenyl-ureido)-cyclohexanecarboxylic acid ethyl ester (4896-09-7)

Guidance literature:

In chloroform; at 0 - 20 ℃; for 3h;

DOI:10.3797/scipharm.aut-01-204

Reference yield:

→ 1-(3-Phenyl-ureido)-cyclohexanecarboxylic acid ethyl ester (4896-09-7)

Guidance literature:

upstream raw materials:

1-amino-cyclohexanecarboxylic acid ethyl ester hydrochloride

phenyl isocyanate

1-aminocyclohexane carboxylic acid

Downstream raw materials:

N₃-phenylcyclohexanespiro-2,4-imidazolidinedione