L-Glutamic acid, N-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]-, di-2-propenyl ester

Base Information

• Chemical Name: L-Glutamic acid, N-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]-, di-2-propenyl ester
• CAS No.: 180839-13-8
• Molecular Formula: C19H24N2O6
• Molecular Weight: 376.409
• Mol file: 180839-13-8.mol

Synonyms:

Chemical Property of L-Glutamic acid, N-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]-, di-2-propenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Glutamic acid, N-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]-, di-2-propenyl ester

There total 9 articles about L-Glutamic acid, N-[[[4-(hydroxymethyl)phenyl]amino]carbonyl]-, di-2-propenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

C25H38N2O6Si (848004-43-3) → diprop-2-enyl N-<(4-phenyl)carbamoyl>-L-glutamate (180839-13-8)

Guidance literature:

C₂₅H₃₈N₂O₆Si; With water; acetic acid; In tetrahydrofuran; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 ℃;

Reference yield: 63.0%

4-aminobenzenemethanol (623-04-1) + diallyl L-glutamylisocyanate (180839-12-7) → diprop-2-enyl N-<(4-phenyl)carbamoyl>-L-glutamate (180839-13-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; toluene; for 0.25h; Ambient temperature;

DOI:10.1021/jm980696v

Reference yield: 52.0%

bis(trichloromethyl) carbonate (32315-10-9) + diallyl glutamate hydrochloride (1128075-52-4) + 4-aminobenzenemethanol (623-04-1) → diprop-2-enyl N-<(4-phenyl)carbamoyl>-L-glutamate (180839-13-8)

Guidance literature:

bis(trichloromethyl) carbonate; L-glutamic acid diallyl ester hydrochloride; With triethylamine; In toluene; at -78 ℃; for 0.5h;

4-aminobenzenemethanol; With triethylamine; In tetrahydrofuran; at 20 ℃; for 1h;

upstream raw materials:

diprop-2-enyl N-<(4-<<2'-tetrahydropyranyl>oxymethyl>phenyl)carbamoyl>-L-glutamate

4-aminobenzenemethanol

diallyl L-glutamylisocyanate

diallyl glutamate para-toluenesulfonic acid

Downstream raw materials:

(S)-2-[3-(4-{2-[(S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-pyrrolidine-1-carbonyl]-4,5-dimethoxy-phenylcarbamoyloxymethyl}-phenyl)-ureido]-pentanedioic acid diallyl ester

diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenyl)carbamoyl>-L-glutamate

diprop-2-enyl N-<(4-<<4-(bis<2-chloroethyl>amino)phenoxycarbonyloxy>methyl>phenyl)carbamoyl>-L-glutamate

bis-allyl p-nitrobenzyloxycarbonyloxy-p-benzylaminocarbonyl-L-glutamate