4-(2-Chloroacetamido)-2,2,6,6-tetramethylpiperidine1-oxyl

Base Information

• Chemical Name: 4-(2-Chloroacetamido)-2,2,6,6-tetramethylpiperidine1-oxyl
• CAS No.: 36775-23-2
• Molecular Formula: C11H21ClN2O2
• Molecular Weight: 247.74
• European Community (EC) Number: 679-651-3
• DSSTox Substance ID: DTXSID50957994
• Nikkaji Number: J422.361F
• Mol file: 36775-23-2.mol

Synonyms:4-(2-CHLOROACETAMIDO)-2,2,6,6-TETRAMETHYLPIPERIDINE1-OXYL;4-(2-Chloroacetamido)-TEMPO;DTXSID50957994;MFCD00041858;4-(2-CHLOROACETAMIDO)-2,2,6,6-TETRAMETHYLPIPERIDINE 1-OXYL, FREE RADICAL;[4-[(Chloroacetyl)amino]-2,2,6,6-tetramethyl-1-piperidinyloxy]radical;4-(2-Chloroacetamido)-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical;{4-[(2-Chloro-1-hydroxyethylidene)amino]-2,2,6,6-tetramethylpiperidin-1-yl}oxidanyl;4-(2-Chloroacetamido)-2,2,6,6-tetramethylpiperidine 1-Oxyl Free Radical, 96%

Chemical Property of 4-(2-Chloroacetamido)-2,2,6,6-tetramethylpiperidine1-oxyl

Chemical Property:

• Vapor Pressure: 1.86E-07mmHg at 25°C
• Melting Point: 117 °C
• Boiling Point: 398.3°Cat760mmHg
• Flash Point: 194.7°C
• PSA: 32.34000
• Density: 1.16g/cm³
• LogP: 2.03730
• Storage Temp.: 2-8°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 247.1213306
• Heavy Atom Count: 16
• Complexity: 261

Purity/Quality:

97% ^*data from raw suppliers

4-(2-Chloroacetamido)2,2,6,6-tetramethylpiperidine1-Oxyl ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(CC(CC(N1[O])(C)C)NC(=O)CCl)C

Technology Process of 4-(2-Chloroacetamido)-2,2,6,6-tetramethylpiperidine1-oxyl

There total 4 articles about 4-(2-Chloroacetamido)-2,2,6,6-tetramethylpiperidine1-oxyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tempamine (14691-88-4) + chloroacetic acid (79-11-8) → 4-[(2-chloroacetyl)amino]-2,2,6,6-tetramethyl-1-piperidinyloxyl (36775-23-2)

Guidance literature:

With DCC; In dichloromethane; at 0 - 20 ℃; for 24h;

DOI:10.1039/c3dt50627d

Reference yield: 90.0%

4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl (14691-88-4,78774-22-8) + chloroacetyl chloride (79-04-9) → 4-[(2-chloroacetyl)amino]-2,2,6,6-tetramethylpiperdine-1-oxyl (36775-23-2)

Guidance literature:

With triethylamine; In chloroform; at -10 - 0 ℃;

Reference yield:

2-chloro-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide (70804-01-2) → 4-[(2-chloroacetyl)amino]-2,2,6,6-tetramethylpiperdine-1-oxyl (36775-23-2)

Guidance literature:

With phosphotungstic acid; dihydrogen peroxide; In water; for 48h; Ambient temperature;

DOI:10.1002/hlca.19800630609

upstream raw materials:

2-chloro-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide

4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl

chloroacetyl chloride

tempamine