2-(4-Chlorophenoxy)-n-methoxy-n-methylacetamide

Base Information

• Chemical Name: 2-(4-Chlorophenoxy)-n-methoxy-n-methylacetamide
• CAS No.: 18232-70-7
• Molecular Formula: C10H12ClNO3
• Molecular Weight: 229.663
• DSSTox Substance ID: DTXSID70591359
• Nikkaji Number: J2.448.826H
• Wikidata: Q82485112
• Mol file: 18232-70-7.mol

Synonyms:2-(4-chlorophenoxy)-n-methoxy-n-methylacetamide;18232-70-7;Acetamide, 2-(4-chlorophenoxy)-N-methoxy-N-methyl-;SCHEMBL3868528;DTXSID70591359;MFCD14707539;AKOS006037719;G61994;F1903-0150

Chemical Property of 2-(4-Chlorophenoxy)-n-methoxy-n-methylacetamide

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 229.0505709
• Heavy Atom Count: 15
• Complexity: 205

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C(=O)COC1=CC=C(C=C1)Cl)OC

Technology Process of 2-(4-Chlorophenoxy)-n-methoxy-n-methylacetamide

There total 2 articles about 2-(4-Chlorophenoxy)-n-methoxy-n-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-Chlorophenoxyacetic acid (122-88-3) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → N-methoxy-2-(4-chloro-phenoxy)-N-methyl-acetamide (18232-70-7)

Guidance literature:

4-Chlorophenoxyacetic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 0 - 23 ℃;

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In dichloromethane; at 0 - 10 ℃;

DOI:10.1021/jo802363q

Reference yield:

→ N-methoxy-2-(4-chloro-phenoxy)-N-methyl-acetamide (18232-70-7)

Guidance literature:

p-Cl-Phenoxyacetylchlorid, N-Methoxymethylamin*HCl;

Reference yield: 82.0%

N-methoxy-2-(4-chloro-phenoxy)-N-methyl-acetamide (18232-70-7) → p-chlorophenoxyacetaldehyde (43018-72-0)

Guidance literature:

With Schwartz's reagent; In tetrahydrofuran; at 20 ℃; for 0.166667h;

DOI:10.1021/ja066362+

upstream raw materials:

4-Chlorophenoxyacetic acid

N,O-dimethylhydroxylamine*hydrochloride

Downstream raw materials:

p-chlorophenoxyacetaldehyde

2-(4-chlorophenoxy)-1-[(4-methoxymethoxy)phenyl]ethanone

1-(2-fluoro-pyridin-3-yl)-2-(4-chloro-phenoxy)-ethanone

1-(6-chloro-2-fluoro-pyridin-3-yl)-2-(4-chloro-phenoxy)-ethanone