3-(1H-PYRAZOL-1-YL)ANILINE

Base Information

• Chemical Name: 3-(1H-PYRAZOL-1-YL)ANILINE
• CAS No.: 184097-88-9
• Molecular Formula: C9H9N3
• Molecular Weight: 159.191
• Hs Code.: 2933199090
• Mol file: 184097-88-9.mol

Synonyms:GDTZRPGWZFOSSY-UHFFFAOYSA;3-pyrazolylphenylamine;

Chemical Property of 3-(1H-PYRAZOL-1-YL)ANILINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 37-39 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6))
• Boiling Point: 328.229oC at 760 mmHg
• PKA: 3.75±0.10(Predicted)
• Flash Point: 152.307oC
• PSA: 43.84000
• Density: 1.2g/cm3
• LogP: 2.03570
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

3-(1H-pyrazol-1-yl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(1H-PYRAZOL-1-YL)ANILINE

There total 4 articles about 3-(1H-PYRAZOL-1-YL)ANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-(3-nitrophenyl)-1H-pyrazole (25688-18-0) → 3-(1H-pyrazol-1-yl)aniline (184097-88-9)

Guidance literature:

With palladium 10% on activated carbon; hydrazine hydrate; In ethanol; for 1h; Reflux;

Reference yield: 89.0%

NH-pyrazole (288-13-1) + m-Bromoaniline (591-19-5) → 3-(1H-pyrazol-1-yl)aniline (184097-88-9)

Guidance literature:

With D-galacturonic acid; potassium carbonate; copper(I) bromide; In water; dimethyl sulfoxide; at 80 - 100 ℃; Inert atmosphere; Green chemistry;

DOI:10.1055/s-0039-1690226

Reference yield:

3-nitrophenylhydrazine (619-27-2) → 3-(1H-pyrazol-1-yl)aniline (184097-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / ethanol / 1 h / Heating

2: 68 percent / hydrazine hydrate / Pd/C / ethanol / 1 h / Heating

With hydrazine hydrate; palladium on activated charcoal; In ethanol;

DOI:10.1016/S0040-4020(01)00340-4

upstream raw materials:

1-(3-nitrophenyl)-1H-pyrazole

3-nitrophenylhydrazine

3-fluoro-1-nitrobenzene

NH-pyrazole

Downstream raw materials:

tert-butyl ((1S,2S)-2-((4-((3-(1H-pyrazol-1-yl)phenyl)amino)-5-cyanopyrimidin-2-yl)amino)-3,3-difluorocyclohexyl)carbamate

methyl 1-oxo-2-(2-{[3-(1H-pyrazol-1-yl)phenyl]amino}ethyl)-1,2-dihydroisoquinoline-7-carboxylate

N-(3-(pyrazol-1-yl)phenyl)benzamide

[2-(1H-pyrazolyl-κN2)-6-((diphenylphosphino)amine-κP)phenyl-κCl]palladium(II) chloride