(4-Fluorophenyl)diphenylphosphane

Base Information

• Chemical Name: (4-Fluorophenyl)diphenylphosphane
• CAS No.: 18437-72-4
• Molecular Formula: C18H14FP
• Molecular Weight: 280.281
• DSSTox Substance ID: DTXSID80570397
• Nikkaji Number: J1.565.138E
• Wikidata: Q82457811
• Mol file: 18437-72-4.mol

Synonyms:(4-FLUOROPHENYL)DIPHENYLPHOSPHANE;18437-72-4;Phosphine, (4-fluorophenyl)diphenyl-;(4-fluorophenyl)-diphenylphosphane;(4-Fluorophenyl)(diphenyl)phosphane;SCHEMBL18702923;DTXSID80570397;CS-0040659

Chemical Property of (4-Fluorophenyl)diphenylphosphane

Chemical Property:

• XLogP3: 4.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 280.08171561
• Heavy Atom Count: 20
• Complexity: 255

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)P(C2=CC=CC=C2)C3=CC=C(C=C3)F

Technology Process of (4-Fluorophenyl)diphenylphosphane

There total 17 articles about (4-Fluorophenyl)diphenylphosphane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-fluorophenyl trifluoromethanesulfonate (132993-23-8) + (diphenylphosphino)(p-tolyl)methanone (40841-62-1) → diphenyl (4‐fluorophenyl) phosphine (18437-72-4)

Guidance literature:

With dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); caesium carbonate; In toluene; at 100 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.joc.1c00937

Reference yield: 93.0%

4-fluoro-1-iodobenzene (352-34-1) + (diphenylphosphino)(p-tolyl)methanone (40841-62-1) → diphenyl (4‐fluorophenyl) phosphine (18437-72-4)

Guidance literature:

With palladium diacetate; caesium carbonate; In toluene; at 80 ℃; for 12h; Sealed tube; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.06.088

Reference yield: 83.0%

diphenyl-p-fluorobenzene-phosphine oxide (18437-73-5) → diphenyl (4‐fluorophenyl) phosphine (18437-72-4)

Guidance literature:

diphenyl-p-fluorobenzene-phosphine oxide; With trifluoroacetic anhydride; In 1,4-dioxane; at 20 ℃; for 0.5h; Inert atmosphere;

With 15-crown-5; sodium hydride; sodium hydrogencarbonate; In 1,4-dioxane; at 150 ℃; for 24h; Inert atmosphere;

upstream raw materials:

4-fluoro-1-iodobenzene

Diphenylphosphine oxide

(diphenylphosphino)(p-tolyl)methanone

diphenylphosphane

Downstream raw materials:

Benzyldiphenyl-p-fluorphenylphosphonium

C₁₈H₁₄FPSe

PdCl₂{(C₆H₅)2P(C₆H₄F)}2

Pd(SCN)2((FC₆H₄)P(C₆H₅)2)2