2H-Pyran, tetrahydro-2-[(4-methoxyphenyl)methoxy]-

Base Information

• Chemical Name: 2H-Pyran, tetrahydro-2-[(4-methoxyphenyl)methoxy]-
• CAS No.: 18494-82-1
• Molecular Formula: C13H18O3
• Molecular Weight: 222.284
• DSSTox Substance ID: DTXSID80453893
• Nikkaji Number: J1.205.819E
• Mol file: 18494-82-1.mol

Synonyms:18494-82-1;2H-Pyran, tetrahydro-2-[(4-methoxyphenyl)methoxy]-;2-[(4-methoxyphenyl)methoxy]oxane;2-((4-methoxybenzyl)oxy)tetrahydro-2h-pyran;SCHEMBL8321396;DTXSID80453893;2-(4-Methoxybenzyloxy)tetrahydro-2H-pyran

Chemical Property of 2H-Pyran, tetrahydro-2-[(4-methoxyphenyl)methoxy]-

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 222.125594432
• Heavy Atom Count: 16
• Complexity: 188

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)COC2CCCCO2

Technology Process of 2H-Pyran, tetrahydro-2-[(4-methoxyphenyl)methoxy]-

There total 4 articles about 2H-Pyran, tetrahydro-2-[(4-methoxyphenyl)methoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3,4-dihydro-2H-pyran (110-87-2) + 4-Methoxybenzyl alcohol (105-13-5) → 2-(4-methoxy-benzyloxy)-tetrahydro-pyran (18494-82-1)

Guidance literature:

With sulfonic acid functionalized polycyclic aromatic carbon catalyst from glycerol pitch; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.molcata.2011.05.025

Reference yield: 90.0%

3-iodo-2-(4-methoxybenzyloxy)tetrahydro-2H-pyran → 2-(4-methoxy-benzyloxy)-tetrahydro-pyran (18494-82-1)

Guidance literature:

With 1,10-Phenanthroline; iron pentacarbonyl; diisopropylamine; In acetonitrile; at 20 ℃;

DOI:10.1021/acs.orglett.6b02375

Reference yield: 85.0%

3,4-dihydro-2H-pyran (110-87-2) + trimethyl(4-methoxybenzyloxy)silane (14629-56-2) → 2-(4-methoxy-benzyloxy)-tetrahydro-pyran (18494-82-1)

Guidance literature:

With [K*18-crown-6]Br₃; water; In acetonitrile; at 20 ℃; for 0.25h;

DOI:10.1080/00304948.2019.1586430

upstream raw materials:

3,4-dihydro-2H-pyran

4-Methoxybenzyl alcohol

trimethyl(4-methoxybenzyloxy)silane

Downstream raw materials:

4-methoxy-benzaldehyde

4-Methoxybenzyl alcohol

p-methoxybenzyl acetate

p-methoxybenzyl benzoate