Benzene, 1,3,5-trimethyl-2-(methylsulfinyl)-, (R)-

Base Information

• Chemical Name: Benzene, 1,3,5-trimethyl-2-(methylsulfinyl)-, (R)-
• CAS No.: 18689-86-6
• Molecular Formula: C10H14OS
• Molecular Weight: 182.287
• Mol file: 18689-86-6.mol

Synonyms:

Chemical Property of Benzene, 1,3,5-trimethyl-2-(methylsulfinyl)-, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1,3,5-trimethyl-2-(methylsulfinyl)-, (R)-

There total 9 articles about Benzene, 1,3,5-trimethyl-2-(methylsulfinyl)-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

methylmagnesium bromide (75-16-1) + benzyl (2S,4S,5R)-4-methyl-5-phenyl-1,2,3-oxathiazolidine-2-oxide-3-carboxylate (499140-11-3) + 2-mesitylmagnesium bromide (2633-66-1) → (1R,2S)-1-phenyl-2-benzyloxycarbonylamino-1-propanol (104863-92-5) + (R)-methyl mesityl sulfoxide (18689-86-6)

Guidance literature:

benzyl (2S,4S,5R)-4-methyl-5-phenyl-1,2,3-oxathiazolidine-2-oxide-3-carboxylate; 2-mesitylmagnesium bromide; In dichloromethane; at -78 ℃;

With tetrafluoroboric acid; In dichloromethane; for 0.0833333h;

methylmagnesium bromide; In dichloromethane;

DOI:10.1021/ol027232i

Reference yield:

1,3,5-trimethyl-2-(methylsulfinyl)benzene (7321-59-7) → (R)-methyl mesityl sulfoxide (18689-86-6) + (S)-(2,4,6)-trimethylphenyl methyl sulfoxide (82079-40-1)

Guidance literature:

With D-Glucose; In aq. phosphate buffer; hexane; isopropyl alcohol; at 37 ℃; for 24h; Resolution of racemate; Inert atmosphere;

DOI:10.1016/j.apcata.2012.06.050

Reference yield:

methyl mesityl sulphide (7570-91-4) → (R)-methyl mesityl sulfoxide (18689-86-6) + (S)-(2,4,6)-trimethylphenyl methyl sulfoxide (82079-40-1)

Guidance literature:

With 6-aza-5β,6β-epoxy-cholestane-based tetrafluoroborate salt; In dichloromethane; at -70 - 20 ℃; for 3h; Title compound not separated from byproducts.;

DOI:10.1021/ol0702573

upstream raw materials:

methyllithium

2,4,6-Trimethyl-benzenesulfinic acid (S)-2-hydroxy-1-methyl-2,2-diphenyl-ethyl ester

methylmagnesium bromide

benzyl (2S,4S,5R)-4-methyl-5-phenyl-1,2,3-oxathiazolidine-2-oxide-3-carboxylate

Downstream raw materials:

(S,S)-1,1-bis-(mesitylsulfinyl)-methane