1-(2-bromoethoxy)-3,5-dichlorobenzene

Base Information

• Chemical Name: 1-(2-bromoethoxy)-3,5-dichlorobenzene
• CAS No.: 18800-31-2
• Molecular Formula: C8H7BrCl2O
• Molecular Weight: 269.95100
• Mol file: 18800-31-2.mol

Synonyms:

Chemical Property of 1-(2-bromoethoxy)-3,5-dichlorobenzene

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Boiling Point: 311.216oC at 760 mmHg
• Flash Point: 142.018oC
• PSA: 9.23000
• Density: 1.616g/cm3
• LogP: 3.76710

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Bromoethoxy)-3,5-dichlorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-bromoethoxy)-3,5-dichlorobenzene

There total 2 articles about 1-(2-bromoethoxy)-3,5-dichlorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dichlorophenol (591-35-5) + ethylene dibromide (106-93-4) → 1-(2-bromo-ethoxy)-3,5-dichloro-benzene (18800-31-2)

Guidance literature:

With sodium hydroxide;

Reference yield:

1,1-Dibromoethane (557-91-5) + 3,5-dichlorophenol (591-35-5) → 1-(2-bromo-ethoxy)-3,5-dichloro-benzene (18800-31-2)

Guidance literature:

With sodium hydroxide; In water; ethyl acetate;

Reference yield:

1-(2-bromo-ethoxy)-3,5-dichloro-benzene (18800-31-2) → 7-{[2-(3,5-Dichloro-phenoxy)-ethyl]-methanesulfonyl-amino}-heptanoic acid

Guidance literature:

Multi-step reaction with 5 steps

1: diethyl ether; chloroform; water; N,N-dimethyl-formamide

2: hydrazine hydrate / methanol; diethyl ether

3: triethylamine

4: hydrogenchloride; NaH / ethyl acetate; N,N-dimethyl-formamide

5: sodium hydroxide / methanol; dichloromethane

With hydrogenchloride; sodium hydroxide; NaH; hydrazine hydrate; triethylamine; In methanol; diethyl ether; dichloromethane; chloroform; water; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

3,5-dichlorophenol

ethylene dibromide

1,1-Dibromoethane

Downstream raw materials:

N-<2-(3.5-Dichlorphenoxy)-ethyl>-cyclopropylamin

N-<2-(2.3-Dichlorphenoxy)-ethyl>-cyclopropylamin

2-(3,5-dichloro-phenoxy)-ethylamine

Refernces

• 1、 -. "Prostaglandin agonists and their use to treat bone disorders". . . Retrieved 2008/06/13.
• 2、 -. "Prevention of loss and restoration of bone mass by certain prostaglandin agonists". . . Retrieved 2008/06/13.