2-(3-methylphenyl)quinazolin-4-ol

Base Information

• Chemical Name: 2-(3-methylphenyl)quinazolin-4-ol
• CAS No.: 18818-40-1
• Molecular Formula: C15H12N2O
• Molecular Weight: 236.273
• Mol file: 18818-40-1.mol

Synonyms:2-(3-methylphenyl)quinazolin-4(3H)-one;2-(3-METHYLPHENYL)-4(3H)-QUINAZOLINONE;2-m-tolylquinazolin-4(3H)-one;2-m-tolyl-3H-quinazolin-4-one;2-(m-tolyl)quinazolin-4(3H)-one;2-(3-tolyl)quinazolin-4(3H)-one;

Chemical Property of 2-(3-methylphenyl)quinazolin-4-ol

Chemical Property:

• PSA: 45.75000
• LogP: 2.89850

Purity/Quality:

99% ^*data from raw suppliers

2-(3-METHYLPHENYL)-4(3H)-QUINAZOLINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-methylphenyl)quinazolin-4-ol

There total 41 articles about 2-(3-methylphenyl)quinazolin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-methylbenzyl alcohol (587-03-1) + anthranilic acid amide (28144-70-9,88-68-6) → 2-(3-methylphenyl)-4(3H)-quinazolinone (18818-40-1)

Guidance literature:

With potassium hydroxide; In toluene; at 90 ℃; for 20h;

DOI:10.1007/s00706-015-1434-7

Reference yield: 98.0%

o-fluorobromobenzene (1072-85-1) + carbon monoxide (201230-82-2) + 3-methylbenzenecarboximidamide hydrochloride (20680-59-5) → 2-(3-methylphenyl)-4(3H)-quinazolinone (18818-40-1)

Guidance literature:

With palladium diacetate; N-ethyl-N,N-diisopropylamine; catacxium A; In N,N-dimethyl acetamide; at 140 ℃; for 22h; under 7500.75 Torr; Inert atmosphere; Autoclave;

DOI:10.1002/chem.201405221

Reference yield: 97.0%

3-methyl-benzenemethanamine (100-81-2) + anthranilic acid amide (28144-70-9,88-68-6) → 2-(3-methylphenyl)-4(3H)-quinazolinone (18818-40-1)

Guidance literature:

With copper(l) iodide; 1,10-phenanthroline-5,6-dione; toluene-4-sulfonic acid; In chlorobenzene; at 100 ℃; for 24h; under 760.051 Torr;

DOI:10.1039/d0cy01764g

upstream raw materials:

N-m-toluoyl-anthranilic acid methyl ester

N-(2-cyanophenyl)-3-methylbenzamide

2-(3-Methylbenzamido)benzamide

2-nitro-N,N-diethylbenzamide