Butanoic acid, 2-diazo-4,4,4-trifluoro-3-oxo-, ethyl ester

Base Information

• Chemical Name: Butanoic acid, 2-diazo-4,4,4-trifluoro-3-oxo-, ethyl ester
• CAS No.: 18955-75-4
• Molecular Formula: C6H5F3N2O3
• Molecular Weight: 210.113
• Mol file: 18955-75-4.mol

Synonyms:ethyl 2-diazo-3-oxo-4,4,4-trifluorobutyrate;ethyl 2-diazo-4,4,4-trifluoroacetoacetate;BUTANOIC ACID, 2-DIAZO-4,4,4-TRIFLUORO-3-OXO-, ETHYL ESTER;ethyl 4,4,4-trifluoro-3-oxobutanoate;1,1,1-trifluoro-3-diazoacetoacetate;Ethyl trifluoromethylacetoacetate;ethyl 2-diazo-4,4,4-trifluoro-3-oxobutanoate;

Chemical Property of Butanoic acid, 2-diazo-4,4,4-trifluoro-3-oxo-, ethyl ester

Chemical Property:

• PSA: 80.76000
• LogP: 0.43276

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Butanoic acid, 2-diazo-4,4,4-trifluoro-3-oxo-, ethyl ester

There total 5 articles about Butanoic acid, 2-diazo-4,4,4-trifluoro-3-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

diazoacetic acid ethyl ester (623-73-4) + trifluoroacetic anhydride (407-25-0) → ethyl 2-diazo-3-oxo-4,4,4-trifluorobutyrate (18955-75-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 ℃;

DOI:10.1016/0022-1139(94)03081-2

Reference yield: 84.0%

ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → ethyl 2-diazo-3-oxo-4,4,4-trifluorobutyrate (18955-75-4)

Guidance literature:

With 4-toluenesulfonyl azide; triethylamine; In benzene; for 12h; Ambient temperature;

DOI:10.1016/0022-1139(94)03081-2

Reference yield: 79.0%

2-benzofuroyl azide (65847-71-4) + ethyl 4,4,4-trifluoroacetoacetate (372-31-6) → ethyl 2-diazo-3-oxo-4,4,4-trifluorobutyrate (18955-75-4) + 4-(trifluoromethyl)benzofuro[2,3-b]pyridin-2(1H)-one (1018966-58-9)

Guidance literature:

2-benzofuroyl azide; With acetic acid; In water; N,N-dimethyl-formamide; Reflux;

ethyl 4,4,4-trifluoroacetoacetate; With acetic acid; In water; N,N-dimethyl-formamide; regiospecific reaction; Reflux;

DOI:10.1055/s-0029-1217396

upstream raw materials:

diazoacetic acid ethyl ester

trifluoroacetic anhydride

ethyl 4,4,4-trifluoroacetoacetate

2-benzofuroyl azide

Downstream raw materials:

ethyl 4,4,4-trifluoro-3-oxo-2-(triphenyl-λ⁵-phosphanylidenehydrazono)butanoate

Trifluoracetyl-glyoxylsaeure-aethylester-triphenylphosphazin-⁽²⁾