1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-2-[(4-methoxyphenyl)methyl]-1-[[(R)-(4-methylphenyl) sulfinyl]methyl]-, (1S)-

Base Information

Chemical Name:1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-2-[(4-methoxyphenyl)methyl]-1-[[(R)-(4-methylphenyl) sulfinyl]methyl]-, (1S)-
CAS No.:190279-18-6
Molecular Formula:C27H28N2O2S
Molecular Weight:444.598
Hs Code.:
Mol file:190279-18-6.mol

Synonyms:

Suppliers and Price of 1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-2-[(4-methoxyphenyl)methyl]-1-[[(R)-(4-methylphenyl) sulfinyl]methyl]-, (1S)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-2-[(4-methoxyphenyl)methyl]-1-[[(R)-(4-methylphenyl) sulfinyl]methyl]-, (1S)-

Chemical Property:

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Technology Process of 1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-2-[(4-methoxyphenyl)methyl]-1-[[(R)-(4-methylphenyl) sulfinyl]methyl]-, (1S)-

There total 3 articles about 1H-Pyrido[3,4-b]indole, 2,3,4,9-tetrahydro-2-[(4-methoxyphenyl)methyl]-1-[[(R)-(4-methylphenyl) sulfinyl]methyl]-, (1S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 7390-67-2
2-(1H-indol-3-yl)-N-(4-methoxybenzyl)ethan-1-amine

: 391869-91-3
4,4,6-Trimethyl-2-((R)-toluene-4-sulfinylmethyl)-[1,3]oxazinane

: 190279-13-1
(1R,S_R)-N-(p-methoxybenzyl)-1-(p-tolylsulfinylmethyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

: 190279-18-6
(1S,S_R)-N-(p-methoxybenzyl)-1-(p-tolylsulfinylmethyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

Guidance literature:: With acetic acid; In acetonitrile; for 24h; Heating;
DOI:10.1016/j.tet.2004.07.062

Reference yield:

: 1517-82-4
(1R,2S,5R,SS)-(-)-menthyl p-toluenesulfinate

: 190279-18-6
(1S,S_R)-N-(p-methoxybenzyl)-1-(p-tolylsulfinylmethyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 84 percent / tetrahydrofuran; hexane / 2.5 h / -78 °C

2.1: 100 percent / NaBH₄; HCl / ethanol; tetrahydrofuran; H₂O / 1 h / -45 °C / pH 7 - 8

3.1: 56 percent / AcOH / acetonitrile / 24 h / Heating

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; acetic acid; In tetrahydrofuran; ethanol; hexane; water; acetonitrile;
DOI:10.1016/j.tet.2004.07.062

Reference yield:

: 391869-90-2
4,4,6-trimethyl-2-(toluene-4-sulfinylmethyl)-5,6-dihydro-4H-[1,3]oxazine

: 190279-18-6
(1S,S_R)-N-(p-methoxybenzyl)-1-(p-tolylsulfinylmethyl)-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / NaBH₄; HCl / ethanol; tetrahydrofuran; H₂O / 1 h / -45 °C / pH 7 - 8

2: 56 percent / AcOH / acetonitrile / 24 h / Heating

With hydrogenchloride; sodium tetrahydroborate; acetic acid; In tetrahydrofuran; ethanol; water; acetonitrile;
DOI:10.1016/j.tet.2004.07.062