1,4-Naphthalenedione, 2-[(2-hydroxyphenyl)amino]-

Base Information

Chemical Name:1,4-Naphthalenedione, 2-[(2-hydroxyphenyl)amino]-
CAS No.:19073-35-9
Molecular Formula:C16H11NO3
Molecular Weight:265.268
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Chemical Property of 1,4-Naphthalenedione, 2-[(2-hydroxyphenyl)amino]-

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General Description 1,4-Naphthalenedione, 2-[(2-hydroxyphenyl)amino]- (also known as 2-[(o-hydroxyphenyl)amino]-1,4-naphthaquinone or HAN) is an aminoquinone derivative synthesized from lawsone. It exhibits a crystalline structure in the orthorhombic space group *Pca2₁*, forming intermolecular hydrogen-bonded chains via O–H···O and C–H···O interactions. In solution, it demonstrates dimerization in *d₆*-DMSO but exists as a monomer in CDCl₃, as supported by ¹H NMR and cyclic voltammetry studies. Theoretical calculations further confirm its hydrogen-bonding behavior and electrochemical properties. Additionally, HAN has been investigated for its potential cytotoxicity and apoptosis-inducing activity.

Technology Process of 1,4-Naphthalenedione, 2-[(2-hydroxyphenyl)amino]-

There total 9 articles about 1,4-Naphthalenedione, 2-[(2-hydroxyphenyl)amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%