N'-[3-(2-chlorophenothiazin-10-yl)propyl]-N,N,N'-trimethylpropane-1,3-diamine

Base Information

Chemical Name:N'-[3-(2-chlorophenothiazin-10-yl)propyl]-N,N,N'-trimethylpropane-1,3-diamine
CAS No.:19077-20-4
Molecular Formula:C21H28ClN3S
Molecular Weight:389.98500
Hs Code.:
UNII:Q5S3FXN3C4
Mol file:19077-20-4.mol

Synonyms:19077-20-4;Q5S3FXN3C4;N'-[3-(2-chlorophenothiazin-10-yl)propyl]-N,N,N'-trimethylpropane-1,3-diamine;2-Chloro-10-[3-[[3-(dimethylamino)propyl]methylamino]propyl]phenothiazine;N1-(3-(2-Chloro-10H-phenothiazin-10-yl)propyl)-N1,N3,N3-trimethylpropane-1,3-diamine;Phenothiazine, 2-chloro-10-(3-((3-(dimethylamino)propyl)methylamino)propyl)-;1,3-Propanediamine, N-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-N,N',N'-trimethyl-;1,3-Propanediamine, N1-(3-(2-chloro-10H-phenothiazin-10-yl)propyl)-N1,N3,N3-trimethyl-;N-(3-(2-Chloro-10H-phenothiazin-10-yl)propyl)-N,N,N-trimethylpropane-1,3-diamine;N1-(3-(2-Chloro-10H-phenothiazin-10-yl)propyl)-N1,N3,N3-trimethyl-1,3-propanediamine;Chlorpromazine EP Impurity B;UNII-Q5S3FXN3C4;TUQCMXWJPGAJBI-UHFFFAOYSA-N;Chlorpromazine hydrochloride impurity B [EP];CHLORPROMAZINE HYDROCHLORIDE IMPURITY B [EP IMPURITY]

Suppliers and Price of N'-[3-(2-chlorophenothiazin-10-yl)propyl]-N,N,N'-trimethylpropane-1,3-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 9 raw suppliers

Chemical Property of N'-[3-(2-chlorophenothiazin-10-yl)propyl]-N,N,N'-trimethylpropane-1,3-diamine

Chemical Property:

Boiling Point:507.5±50.0 °C(Predicted)
PKA:9.58±0.28(Predicted)
PSA：35.02000
Density:1.160±0.06 g/cm3(Predicted)
LogP:5.28130
XLogP3:5.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:8
Exact Mass:389.1692468
Heavy Atom Count:26
Complexity:422

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CN(C)CCCN(C)CCCN1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl

Technology Process of N'-[3-(2-chlorophenothiazin-10-yl)propyl]-N,N,N'-trimethylpropane-1,3-diamine

There total 2 articles about N'-[3-(2-chlorophenothiazin-10-yl)propyl]-N,N,N'-trimethylpropane-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 2765-59-5
2-chloro-10-(3-chloropropyl)-10H-phenothiazine

: 4543-96-8
N,N,N'-trimethylpropane-1,3-diamine

: 19077-20-4
2-chloro-10-(3-(N-(3-dimethylamino)propyl-N-methyl)amino)propyl-10H-phenothiazine

Guidance literature:: In butan-1-ol; for 18h; Heating;
DOI:10.1016/S0006-2952(01)00840-1

Reference yield:

: 92-39-7
2-chlorophenothiazine

: 19077-20-4
2-chloro-10-(3-(N-(3-dimethylamino)propyl-N-methyl)amino)propyl-10H-phenothiazine

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / NaH / dimethylsulfoxide; tetrahydrofuran / 20 °C

2: 82 percent / butan-1-ol / 18 h / Heating

With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; butan-1-ol;
DOI:10.1016/S0006-2952(01)00840-1